HIV Infections Clinical Trial
Official title:
Adult AIDS Clinical Trials Group Longitudinal Linked Randomized Trials (ALLRT) Protocol
The purpose of this study is to determine what combinations of anti-HIV drugs work best in patients treated over several years. The study will also assess the occurrence of side effects and opportunistic infections in patients with low viral loads compared to those with higher viral loads.
A compilation of outcomes of various antiretroviral therapies would be beneficial when
evaluating which strategies are most effective in long-term treatment of HIV-1. Using data
from present and recently completed studies, this study will collect information on
therapies and their control of HIV infection and maintenance of durable suppression of HIV-1
replication.
No treatment is provided by this study, but patients will continue to receive highly active
antiretroviral therapy (HAART) from other studies in which they are coenrolled. Blood and
urine collection will occur at study entry and periodically throughout the study. Women may
undergo pelvic exams and Pap smears. Portions of blood samples will be stored to evaluate
genotypic/phenotypic susceptibility testing. Medical histories, physical exams, and
questionnaires will be completed periodically.
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Observational Model: Cohort, Time Perspective: Prospective
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