HIV Infection Clinical Trial
Official title:
HIV Infection and Gut Mucosal Immune Function: Longitudinal Analyses of Intestinal CD4+ and Th17 T Cells in HIV-infected Individuals on Short-term Antiretroviral Therapy
HIV infection is associated with a state of chronic, generalized immune activation that has
been shown in many studies to be a key predictor of progression to AIDS. The molecular,
cellular, and pathophysiological mechanisms underlying the HIV-associated immune activation
are complex and still poorly studied. There is, however, growing consensus that both viral
and host factors contribute to this phenotype, with emphasis on the role played by the
mucosal immune dysfunction (and consequent microbial translocation). Moreover if it is known
that in HIV-infected individuals, a severe depletion of intestinal cluster of
differentiation 4 (CD4+) T-cells, is associated with loss of epithelium integrity, microbial
translocation and systemic immune activation, the kinetics of intestinal CD4+ T-cell
reconstitution under combined antiretroviral therapy (cART) remains poorly understood.
This study sought to evaluate the reconstitution of intestinal CD4+ T-cells, including Th1
and Th17, in blood and colon samples collected from HIV-infected individuals before and
after a short term cART.
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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