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Pharmacokinetic Study of Posaconazole Boosted Fosamprenavir — EPOS  

HIV Infection Clinical Trial

Official title:
Pharmacokinetic Study of Posaconazole Boosted Fosamprenavir

Clinical Trial Summary

The purpose of this study is to determine the influence of posaconazole on unboosted fosamprenavir pharmacokinetics, and vice versa, in healthy volunteers.A second objective is to determine the safety of combined use of fosamprenavir with posaconazole in healthy volunteers.

Clinical Trial Description

Infections with fungi and yeast frequently occur in patients infected with the human immunodeficiency virus type 1 (HIV-1). Fosamprenavir is a PI that is used to treat HIV-infection in combination with ritonavir. Once hydrolyzed to amprenavir, this substance is a substrate for CYP3A4. Ritonavir is an extremely potent inhibitor of CYP3A4 and serves as a booster of the pharmacokinetics of amprenavir. Posaconazole is a very potent CYP3A4 inhibitor and therefore might enhance amprenavir pharmacokinetics in a similar way as ritonavir. The current study is designed to test this hypothesis. When there is an indication for antifungal therapy in an HIV-infected patient, temporal replacement of ritonavir by posaconazole would be an attractive option for combined treatment of HIV and fungal infection. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00817765
Study type Interventional
Source Radboud University
Contact
Status Completed
Phase Phase 1
Start date January 2009
Completion date October 2009
View Details
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