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A Prospective Cohort for ex Vivo Cure Studies With Chronic HIV Infected Patients in the Netherlands — CHRONO  

HIV Infections Clinical Trial

Official title:
A Prospective Cohort for ex Vivo Cure Studies With Chronic HIV Infected Patients in the Netherlands: The CHRONO Project

Clinical Trial Summary

A prospective non-interventional cohort study at Erasmus MC of adult chronic HIV infected patients of ≥18 years of age who initiate antiretroviral therapy in routine care.

Clinical Trial Description

HIV cannot be cured with the current treatment armamentarium. A reservoir of latently HIV infected long lived CD4+T-cells is present in patients with HIV that are not affected by antiretroviral therapy. The evolution of this reservoir after therapy initiation is ill understood, as are the potential strategies to eradicate this reservoir. This study aims to anticipate on future HIV cure strategies by building a cohort to study ex vivo the reservoirs of HIV patients, the obstacles to cure HIV, and new therapeutic compounds and strategies. Main study parameters/endpoints: 1. Change in viral reservoir size after antiretroviral treatment initiation. 2. Evolution of phenotypical and functional aspects of the anti-HIV host immune responses. 3. Ex vivo activity of established and novel HIV latency reversing agents. 4. Variance in HIV reservoir and host immunity between HIV subtypes and clinical variables. A project from the Erasmus MC HIV Eradication Group (EHEG). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04888754
Study type Observational
Source Erasmus Medical Center
Contact
Status Active, not recruiting
Phase
Start date May 26, 2021
Completion date January 2034
View Details
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