Lidocaine Infusion for Pain After Herniotomy — LIPAH  

Chronic Pain Clinical Trial

Official title: Lidocaine Infusion for Pain After Herniotomy (LIPAH), A Randomized Placebo-controlled Trial (LIPAH Trial)

Status Recruiting

Clinical Trial Summary

This study seeks to investigate lidocaine infusion to reduce occurrence of chronic postoperative pain at 3-month after inguinal herniotomy

Clinical Trial Description

Inguinal hernia repair is associated with a 5%-30% incidence of chronic pain; however, the pathogenesis remains unknown, and few studies have assessed chronic pain as the primary aim of the study. Lidocaine infusion could be a possible approach to reducing the prevalence of chronic pain after herniotomy. Recently, a meta-analysis concluded a modest but statistically significant reduction of pain severity in the first four postoperative hours measured by the visual analogue scale (mean difference, -0.84; 95% CI, -1.10 to -0.59). However, a more recent meta-analysis found that only limited clinical data and biological plausibility support lidocaine infusions for the prevention of postoperative persistent pain (odds ratio, 0.29; 95% CI, 0.18 to 0.48). This study was designed to investigate whether lidocaine infusion after inguinal herniotomy would lower the incidence of chronic postoperative pain. ;

Related Conditions & MeSH terms

• Chronic Pain
• Hernia, Inguinal
• Lidocaine
• Pain, Postoperative

• NCT number: NCT03673163
• Study type: Interventional
• Source: Guangzhou First People's Hospital
• Contact: Xiangcai Ruan, PhD
• Phone: +8620-81048306
• Email: xc_ruan@hotmail.com
• Status: Recruiting
• Phase: N/A
• Start date: November 6, 2018
• Completion date: June 30, 2019