Hepatocellular Carcinoma Clinical Trial
Official title:
A Phase II Study of Intra-arterial Chemotherapy With Cisplatin and Mitomycin-C
This study is for people with cancer of the liver that cannot be completely removed by
surgery. This study involves giving the drugs mitomycin-C and cisplatin, into an artery in
the liver. Mitomycin-C is a drug that has been approved by the FDA to treat cancer of the
stomach and pancreas. Mitomycin-C is a drug that causes cancer cells to die and prevents them
from reproducing. Cisplatin is also a drug that has been approved by the FDA. Cisplatin is
approved to treat cancer of the testes, ovaries, lung, esophagus, bladder, head and neck.
Cisplatin is a drug that prevents cancer cells from reproducing. The purpose of this study is
to see how long it takes subjects' tumor(s) to grow after receiving the study drugs. Another
purpose of this study is to look at the side effects of this study therapy and how long
subjects survive after receiving it.
An additional purpose of this study is to see how well we can predict subjects' response to
the study therapy, based on blood and tumor tissue tests. These tests will measure the levels
of genes (the cell's blueprint) in subjects' tumors and blood. These genes affect how
people's bodies react to the cancer drugs.
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