Heart Failure Clinical Trial
Official title:
Effects of Polyphenols on Changes of Inflammatory and Cardiovascular Status After a Marathon Run
The purpose of the study is to determine the myocardial function and vascular adaptation after strenuous exercise in association with consumption of polyphenols. The investigators aim to investigate the effects of extreme endurance exercise on the inflammatory system. Furthermore, the role of the cardiovascular response and adaptive mechanisms of the vasculature are examined. Subclinical injuries to the myocardium and vascular wall are being investigated.
Regular exercise leads to an improvement of cardiovascular risk factors in patients with
coronary heart disease, atherosclerosis and metabolic disorders.
Aerobic exercise has anti-inflammatory effects. In contrast, the exertional exercise of
marathon running causes an acute pro-inflammatory impulse. This may lead to myocardial
injury and, in case of preexisting plaques, may result in plaque rupture and acute
myocardial infarction.
We aim to define the critical role of inflammatory markers and cardiovascular risc factors
as a predictor of an increased risk for myocardial and endothelial dysfunction in marathon
runners.
Diagnostic tools include measurements of microvasculature, the large vessels and
echocardiography. Inflammatory markers include high sensitive c-reactive protein (CRP) and
interleukins.
All variations are analysed on the basis of consumption of polyphenols as they are found in
in hops (Humulus lupus L.) and beer.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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