Heart Failure Clinical Trial
Official title:
Investigating the Interaction of Apelin and Systemic Angiotensin II Peripheral Resistance Vessels and Systemic Haemodynamics in Vivo in Man
The apelin-APJ system is a relatively new discovery. It has generated interest in part due
to it's apparent ability to counteract the renin-angiotensin system, which is frequently
overactive in many cardiovascular disease.
Two of the main actions of apelin are to increase the pumping ability of the heart and cause
blood vessels to relax. The investigators wish to assess if these actions are altered in the
setting of normal renin-angiotensin activation and increased renin-angiotensin activity.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Basic Science
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