Heart Failure Clinical Trial
Official title:
Anti-remodeling Effect of High-intensity Interval Training in Patients With Post-infarction Heart Failure on Optimal Treatment
Introduction: Moderate-intensity endurance-training is known to reduce symptoms, increase
exercise tolerance, and improve quality of life in patients with chronic heart failure. The
training benefits have mainly been attributed to adaptations in the peripheral circulation
and skeletal muscle rather than to adaptations in cardiac performance. However attenuation
of left ventricular (LV) remodelling has been documented in some studies. The effects of
high- vs. moderate exercise-intensity on LV-remodelling and endothelial function in patients
with post-infarction heart failure are not definitively established and were studied in the
present study.
Methods: Patients with post-infarction heart failure (45-87 yrs, 22-males, 5-females, all
received b-blockers and ACE-inhibitors, EF 29%, peak oxygen uptake 13 ml/kg/min) were
randomized to 12-weeks, 2-3 times per week, of either moderate exercise-intensity (70% of
peak heart rate), high-intensity interval-training (95% of peak heart rate) or to a control
group that received advise from their regular doctors. Patients in the two exercise-groups
covered similar distance on the treadmill at each exercise-session so that only
exercise-intensity differed; i.e. the duration of exercise was longer in the
moderate-intensity group. Ultrasound was used to assess LV-dimension and function (including
Tissue Doppler Imaging, TDI) and endothelial function in the brachial-artery.
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