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Developing Oral LT3 Therapy for Heart Failure - HFrEF — DOT3HF-HFrEF  

Heart Failure With Reduced Ejection Fraction Clinical Trial

Official title:
Developing Oral LT3 Therapy For Heart Failure With Reduced Ejection Fraction

Clinical Trial Summary

Investigation of the safety, feasibility, and preliminary efficacy of thyroid hormone therapy with Liothyronine (LT3) in individuals with heart failure with reduced ejection fraction (HFrEF) and low triiothyronine (T3) syndrome by conducting a randomized, double-blind, placebo-controlled cross-over study with a two week washout period between treatments.

Clinical Trial Description

The overall goal is to determine the safety, feasibility, and preliminary efficacy of administering oral LT3 therapy in the study population of participants with heart failure with reduced ejection fraction (HFrEF). Each treatment period will be approximately 8 weeks in duration, with weekly titration of study drug for 4 weeks, followed by a maintenance dose for 4 weeks, then 2-week washout before crossing over to the other arm (placebo or drug). LT3 will be titrated to T3 levels. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04112316
Study type Interventional
Source University of Pennsylvania
Contact
Status Completed
Phase Phase 1/Phase 2
Start date February 11, 2020
Completion date August 31, 2023
View Details
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