Heart Failure Clinical Trial
To examine the natural history of mortality due to coronary heart disease in post-myocardial infarction patients from the Beta-Blocker Heart Attack Trial (BHAT) and the Aspirin Myocardial Infarction Study (AMIS).
BACKGROUND:
In January 1990, the National Heart, Lung, and Blood Institute issued a Program Announcement
establishing a Small Grants Program to provide limited support to extend analyses of
research data generated by clinical trials, population research, and demonstration and
education studies. This study used data collected in two completed clinical trials, the BHAT
and AMIS.
DESIGN NARRATIVE:
Study endpoints included all-cause mortality, cause-specific mortality such as sudden death,
recurrent and non-fatal myocardial infarction, and incident congestive heart failure.
Univariate and multivariate analyses of baseline data variables from BHAT were conducted to
determine which were predictive of study endpoints. Baseline variables included
sociodemograhic characteristics, medical history, medication use, physical examination
finds, and electrocardiographic characteristics. Baseline characteristics found to be
predictive of study endpoints in the BHAT placebo group were examined in the AMIS placebo
group. Long- and short-term prognoses for patients suffering a transmural myocardial
infarction were compared for those suffering a subendocardial infarction.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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