Effects of Different Concentric and Eccentric Muscle Fatigue Protocols on the Knee Joint Position Sense

Healthy Clinical Trial

Official title:

Effects of Different Concentric and Eccentric Muscle Fatigue Protocols on the Knee Joint Position Sense: a Randomized Controlled Crossover Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06331221
• Other study ID #: JSA_Fatigue_FADEUP
• Status: Recruiting
• Phase: N/A
• Start date: November 2, 2023
• Est. completion date: June 1, 2024

Study information

• Verified date: March 2024
• Source: Universidade do Porto
• Contact: Joana Azevedo, MSc
• Phone: +351917910094
• Email: azevedojoana311[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study was to investigate the effects of different concentric and eccentric muscle fatigue protocols on the knee joint position sense of healthy individuals.

Description:

A randomized controlled crossover trial will be conducted at a biomechanics laboratory with healthy males. All participants will perform with a washout period of 1 week: a control condition (5-minute rest) and 4 local muscle fatigue protocols (concentric of quadriceps; concentric of hamstrings; eccentric of quadriceps; eccentric of hamstrings) in an isokinetic dynamometer at 30º/s. Three maximum voluntary isometric contractions (MVIC) of quadriceps and hamstrings will also be assessed in the beginning of all conditions. Knee joint position sense will be assessed before and immediately after the fatigue protocols/control condition, through active concentric and eccentric positionings/repositionings, in sitting and prone positions, to a target range of 45º of knee flexion in an isokinetic dynamometer. Surface electromyography electrodes will also be placed on the vastus lateralis and biceps femoris during all procedures.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: June 1, 2024
• Est. primary completion date: May 15, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• males aged between 18 and 30 years;
• without current or previous knee pathology or surgery;
• with a low or moderate physical activity level, according to the International Physical Activity Questionnaire;
• normal Body Mass Index (under 24.9 kg/m2), according to the World Health Organization.

Exclusion Criteria:

• those with cardiorespiratory, neurological or vestibular pathologies;
• with positive knee integrity tests (anterior drawer, Lachman's test, posterior drawer; valgus and varus stress testes); and
• those taking any medication that can affect motor control (sedatives, anxiolytics, antibiotics, analgesics, NSAIDs or myorelaxants).

Related Conditions & MeSH terms

• Fatigue
• Healthy

Intervention

Other:
• Muscle fatigue Protocol
Four experimental conditions consisting of different local muscle fatigue protocols performed in the isokinetic dynamometer in random order, with at least one week of interval between them.

Locations

Country	Name	City	State
Portugal	Faculdade de Desporto, Universidade do Porto	Porto

Sponsors (1)

Lead Sponsor	Collaborator
Universidade do Porto

Country where clinical trial is conducted

Portugal, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Absolute angular error	The absolute value of the difference between the target range and the achieved range	Change from Baseline (Before) to Immediately after interventions or control (After)
Primary	Relative angular error	The arithmetic difference between the target range and the range achieved	Change from Baseline (Before) to Immediately after interventions or control (After)
Primary	Variable angular error	The standard deviation of the 3 repositionings	Change from Baseline (Before) to Immediately after interventions or control (After)