Neurofeedback Training for PD

Healthy Clinical Trial

Official title:

EEG- or STN LFP-based Neurofeedback Training for Improving Motor Functions in Parkinson's Disease

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05987865
• Other study ID #: 249990
• Status: Not yet recruiting
• Phase: N/A
• Start date: September 1, 2023
• Est. completion date: August 30, 2026

Study information

• Verified date: July 2023
• Source: University of Oxford
• Contact: Huiling Tan
• Phone: 01865 572483
• Email: huiling.tan[@]ndcn.ox.ac.uk
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this clinical trial is to test neurofeedback training in both people with Parkinson's disease and healthy control.

The main questions it aims to answer are:

• To demonstrate that EEG based or STN LFP based neurofeedback can help patients with Parkinson's disease to volitionally modulate pathological brain activities measured non-invasively;

• To evaluate the learning effect of the neurofeedback training with multiple training sessions

Patient participants will be asked to receive the research intervention called neurofeedback training for maximal three separate sessions. During the intervention, the participants will also be asked to press a pinch meter as fast as possible in order to measure the reaction time, meanwhile, different type of brain signals will be recorded.

. This will be a within-subject cross-over study contrasting the effect of the neurofeedback training and no training.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 40
• Est. completion date: August 30, 2026
• Est. primary completion date: February 28, 2026
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Participants with symptomatic Parkinson's disease or age-matched healthy control

• Adequate understanding of verbal explanation or written information given in English

• Able and willing to give informed consent.

• Normal or corrected-to-normal vision

Exclusion Criteria:

• Lack of capacity to consent (judged by the researcher taking consent as not having sufficient mental capacity to understand the study and its requirements)

Related Conditions & MeSH terms

• Healthy
• Parkinson Disease

Intervention

Behavioral:
• Neurofeedback training
Features related to PD symptoms will be extracted from the brain recordings in real-time and used to drive a visual cursor on a computer screen placed in front of the participant, while the participant will be asked to try to control the cursor by regulating their brain signals.

Locations

Country	Name	City	State
n/a

Sponsors (3)

Lead Sponsor	Collaborator
University of Oxford	King's College Hospital NHS Trust, St George's London University Hospitals NHS Foundation Trust

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The feasibility of using EEG-based neurofeedback to help patients with Parkinson's disease to volitionally modulate pathological brain activities measured non-invasively.	The final position of the cursor and beta power changes after neurofeedback training will be measured and reported.	10 days
Primary	Learning effect of the neurofeedback training with multiple training sessions	The final positions of the cursor and the changes in beta power will be measured and compared across different training sessions.	10 days
Secondary	The effect of EEG-based neurofeedback on motor performance quantified as reaction time in patients with Parkinson's disease	The reaction time following cued motor task will be measured, and compared between training and no-training conditions.	10 days
Secondary	The effect of EEG-based neurofeedback on motor performance quantified as peak movement velocity in patients with Parkinson's disease	The peak movement velocity during the cued motor task will be measured, and compared between training and no-training conditions.	10 days
Secondary	The effect of EEG-based neurofeedback on parkinsonian tremor	The acceleration data will be measured from patient's arms during neurofeedback training, which will be used to quantity the tremor severity by looking at the power at patient specific tremor frequency band. The comparison on tremor severity between training and no-training conditions will be reported.	10 days
Secondary	The effect of EEG-based neurofeedback on motor Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) score	MDS-UPDRS is a comprehensive 50 question assessment of both motor and non-motor symptoms associated with Parkinson's. Each question will be scored between 0 and 5, with a higher value indicates more severe assessment. In this study, the motor part of UPDRS scores on the patients will be measured, and compared before and after neurofeedback training.	10 days
Secondary	The effect of EEG-based neurofeedback on motor performance quantified as reaction time in healthy age-matched control	The reaction time following cued motor task will be measured, and compared between training and no-training conditions in healthy age-matched control group.	10 days
Secondary	The peak movement velocity during the cued motor task will be measured, and compared between training and no-training conditions in healthy age-matched control group.	This will be assessed by comparing the peak movement velocity during the cued motor task between training and no-training conditions.	10 days