Healthy Clinical Trial
— Speed-EnsoOfficial title:
Specificities of the Eccentric Exercise: Energy Expenditure and Nature of Oxidized Substrates
Main objective of this clinical trial is to compare the oxidation rates of main carbohydrate and lipid substrates during exercises carried out in eccentric dynamic pedaling mode on a cycloergometer compared to concentric exercises (classic pedaling) at the same oxygen consumption (VO2). The hypothesis is that lipid oxidation during an eccentric exercise is higher than lipid oxidation during a concentric exercise, done in humans at the capacity of 30% of VO2max.
Status | Recruiting |
Enrollment | 12 |
Est. completion date | August 2023 |
Est. primary completion date | August 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 20 Years to 40 Years |
Eligibility | Inclusion Criteria: - Male volunteers between 20 and 40 years old (20 = years = 40) - Subjects considered healthy by investigator based on the examination, medical and clinical examination - Body Mass Index between 27 and 35 kg/m² (27 < BMI < 35) - Biological check up considered compatible with study participation - Physical check up considered compatible with study participation (no bones, articular or muscular problems) - Person who don't smoke and has no treatment - Person who is in the position to sign informed consent Exclusion Criteria: - Smoking - Person who take any kind of treatments except Paracétamol - All conditions who have interaction with this clinical trial, or who can deteriorate the exercise capacity or the realization of canopy (claustrophobia) - Criteria - Administrative and legal factors - Person who isn't consent - Subject not affiliated with social security - Subject during the exclusion period of a previous study (after verification in the Biomedical Research Volunteers File). |
Country | Name | City | State |
---|---|---|---|
France | CHU clermont-ferrand | Clermont-Ferrand |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Clermont-Ferrand |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Measures of oxidation rate of lipid substrates at T2 visit and T3 visit | The oxidation rate of lipid substrates is measured at 10% of VO2max, 20% of VO2max, 40% of VO2max and 50% of VO2max | Through effort test | |
Secondary | Measures of oxidation rate of carbohydrates at T2 visit and T3 visit | The oxidation rate of carbohydrates is measured at10% of VO2max, 20% of VO2max, 40% of VO2max and 50% of VO2max | Through effort test | |
Secondary | Measure of total energy expenditure at T2 visit and T3 visit | At the T2 visit and T3 visit, the total energy expenditure is measured | Trough exercise | |
Secondary | Measure of total energy expenditure at T2 visit and T3 visit | At the T2 visit and T3 visit, the total energy expenditure is measured | immediatly after exercise | |
Secondary | Measure of total energy expenditure at T2 visit and T3 visit | At the T2 visit and T3 visit, the total energy expenditure is measured | through recovery after exercise, an average of 1 hour | |
Secondary | Measure of total energy expenditure | the total energy expenditure is measured during constant-power cycle ergometer tests. This secondary outcome measure will be measured during eccentric and concentric exercises. | 30 min | |
Secondary | Measure of energy expenditure during 6 hours of recovery after exercises | the energy expenditure is measured during constant-power cycle ergometer tests. This secondary outcome measure will be measured during both kinetics | 6 hours | |
Secondary | Measures of substrates oxidation rates at T4 visit and T5 visit | The oxidation rates of substrates are measured during exercises performed at 30% of VO2max | through effort test | |
Secondary | Measures of quantities of oxidized substrates at T4 visit and T5 visit | The quantities of oxidized substrates (carbohydrates, fats, proteins) are measured during exercises | through effort test | |
Secondary | Measures of quantities of carbohydrates at T4 visit and T5 visit | The quantities of oxidized carbohydrates are measured during the measure of energy expenditure | Through energy expenditure measurment an average of 6 hours | |
Secondary | Measures of quantities of fats at T4 visit and T5 visit | The quantities of fats are measured during the measure of energy expenditure | Through energy expenditure measurment an average of 6 hours |
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