Exploring Muscle Breakdown During Exercise Recovery — EMBER  

Healthy Clinical Trial

Official title: Exploring Muscle Breakdown During Exercise Recovery

Status Completed

Clinical Trial Summary

This study will allow researchers to explore how muscle responds to heavy exercise. The researchers will characterise rates of muscle protein breakdown and synthesis 24hours after heavy exercise with a post exercise protein polyphenol or placebo supplementation. This will inform strategies to help people recover from heavy exercise.

Clinical Trial Description

It is well known that resistance exercise increases rates of muscle protein synthesis and breakdown, with the rise in synthesis greater in magnitude and duration. The time course of rates of muscle protein synthesis increase dramatically 24-72h following eccentric exercise, even in a non-exercised control leg. This data is consistent with a much larger increase in muscle protein breakdown than previously thought. However, the response of muscle protein breakdown following damaging eccentric exercise, and its relationship with muscle protein synthesis, has not yet been elucidated. Moreover, it is unclear whether a protein and polyphenol nutritional intervention influence rates of muscle protein breakdown to accelerate recovery. This study will allow researchers to test the hypothesis that eccentric exercise increases rates of muscle protein breakdown independently of muscle contraction per se. If this hypothesis is supported, it will highlight that recovery strategies from muscle damage should also target supporting muscle protein breakdown. ;

Related Conditions & MeSH terms

• Healthy
• Muscle Damage

• NCT number: NCT04841772
• Study type: Interventional
• Source: University of Exeter
• Status: Completed
• Phase: N/A
• Start date: April 8, 2021
• Completion date: December 1, 2022