Metacognition in Semantic Dementia: Comparison With Alzheimer's Disease

Healthy Clinical Trial

— META-DEM  

Official title:

Metacognition in Semantic Dementia: Comparison With Alzheimer's Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04597827
• Other study ID #: 38RC20.282
• Secondary ID: 2020-A02236-33
• Status: Completed
• Start date: October 16, 2020
• Est. completion date: April 27, 2022

Study information

• Verified date: August 2023
• Source: University Hospital, Grenoble
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study aims at exploring patients' ability to monitor their own memory performance depending on their primary deficit and the type of memory involved in the criterion task. The goal is to evaluate if semantic dementia (SD) and Alzheimer's disease (AD) differently affect patients' awareness of their memory abilities.

Description:

Patients who will give their informed non-opposition will be included. Participants will undergo 6 metacognitive tasks in which they will be tested on newly learnt information (i.e., episodic memory) or prior knowledge (i.e., semantic memory) and asked to evaluate their performance either prior or after the test. Correlation between their evaluation and their actual performance will be measured. Performance and correlations will be compared across groups.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: April 27, 2022
• Est. primary completion date: April 27, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• native French-speakers

• normal or corrected-to-normal vision

• for patients ONLY : doctor-approved diagnosis of semantic dementia or Alzheimer's disease

• for healthy participants ONLY: score above 27 on the MMSE

• non-opposition in participation

Exclusion Criteria:

• other neurological/ psychiatric disorder, or cognitive disorder that might affect general cognition

• drug or alcohol abuse

Related Conditions & MeSH terms

• Alzheimer Disease
• Aphasia, Primary Progressive
• Dementia
• Frontotemporal Dementia
• Healthy
• Pick Disease of the Brain
• Semantic Dementia

Intervention

Other:
• Metacognition tests
Test on episodic or semantic memory

Locations

Country	Name	City	State
France	CHU Angers	Angers
France	CHU Bordeaux	Bordeaux
France	Hôpital Neurologique de Lyon	Bron
France	Hôpitaux Civils Colmar	Colmar
France	Chu Grenoble Alpes	Grenoble
France	CHU Rennes	Rennes
Switzerland	CHU Vaudois	Lausanne

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Grenoble

Countries where clinical trial is conducted

France,  Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Metacognitive bias on the episodic predictive judgment task	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).	End of study : around May 2022
Primary	Metacognitive accuracy on the episodic predictive judgment task	Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.	End of study : around May 2022
Primary	Metacognitive bias on the semantic predictive judgment task	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).	End of study : around May 2022
Primary	Metacognitive accuracy on the semantic predictive judgment task	Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.	End of study : around May 2022
Primary	Metacognitive bias on episodic global judgment task	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).	End of study : around May 2022
Primary	Metacognitive bias on semantic global judgment task	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).	End of study : around May 2022
Primary	Metacognitive bias on the episodic retrospective judgment task	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).	End of study : around May 2022
Primary	Metacognitive accuracy on the episodic retrospective judgment task	Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.	End of study : around May 2022
Primary	Metacognitive bias on the semantic retrospective judgment task	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).	End of study : around May 2022
Primary	Metacognitive accuracy on the semantic retrospective judgment task	Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.	End of study : around May 2022