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Inflammation, Intracellular Invasion and Colonization of the Nasal Mucosa by Staphylococcus Aureus — I3COSa  

Healthy Clinical Trial

Official title:
Inflammation, Intracellular Invasion and Colonization of the Nasal Mucosa by Staphylococcus Aureus

Clinical Trial Summary

An inflammatory state of the nasal cells (very close to keratinocytes) could favour the internalization of Staphylococcus aureus and thus constitute a persistent reservoir for the carriage of this bacterium. Staphylococcus aureus is a commensal bacterium of the skin and mucous membranes that colonizes approximately 2 billion people worldwide Staphylococcus aureus is also a leading cause of community and healthcare-associated infection. Staphylococcus aureus has demonstrated its ability to invade many non-professional phagocytic cell lines such as keratinocytes, osteoblasts, fibroblasts, epithelial cells and endothelial cells. During pro-inflammatory stimulation, internalization of Staphylococcus aureus into keratinocytes is mainly mediated by ICAM-1. These results suggest that, in humans, an inflammatory state of the nasal cells (very close to keratinocytes) could promote the internalization of Staphylococcus aureus and thus constitute a persistent reservoir for the carriage of this bacterium.

Clinical Trial Description

The main objective is to compare the expression level of ICAM-1 in nasal cells with and without the presence of Staphylococcus aureus. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04469348
Study type Interventional
Source Centre Hospitalier Universitaire de Saint Etienne
Contact
Status Completed
Phase N/A
Start date October 18, 2021
Completion date January 9, 2023
View Details
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