Clinical Trials Logo
  1. Home
  2. Healthy
  3. NCT04234295
  4. Details
NCT04234295 Clinical Trial

Investigating the Effect of Obesity on Eosinophil Recruitment in Human Adipose Tissue

Healthy Clinical Trial

Official title:
Investigating the Effect of Obesity on Eosinophil Recruitment in Human Adipose Tissue

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04234295
Other study ID # 19-003803
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date January 29, 2020
Est. completion date January 17, 2022

Study information
Verified date January 2022
Source Mayo Clinic
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Researchers are trying to better understand the relationship between inflammation in adipose tissue (AT) and insulin resistance.

Recruitment information / eligibility
Status Completed
Enrollment 24
Est. completion date January 17, 2022
Est. primary completion date January 17, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 30 Years to 50 Years
Eligibility Inclusion Criteria: - Adults ages 30-50 years - Non-smokers - Lean subjects with a BMI of 25 or less, gender specific normal body fat, - Obese, non-diabetic subjects with a BMI between 30 and 50 and taking no medications affecting glucose metabolism or lipid metabolism - subjects scheduled for an elective laparoscopic or laparotomy abdominal surgery Exclusion Criteria: - Receiving corticosteroid therapy or have a history of asthma, COPD or atopic syndrome - taking any biologic treatment for any autoimmune disorder - Taking any leukotriene receptor antagonist acting medications (ex. Montelukast) - smoking

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Fat Tissue Biopsy
If subjects are scheduled for a surgical procedure a fat sample will be collected during the beginning of the surgery. If subjects are not scheduled for a surgical procedure, a small sample of subcutaneous (superficial) fat tissue from subjects abdomen area will be collected.

Locations
Country Name City State
United States Mayo Clinic Scottsdale Arizona

Sponsors (1)
Lead Sponsor Collaborator
Mayo Clinic

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Other Quantification of the difference in gene methylation in eosinophils from lean and obese subjects Gene methylation of eosinophils will be quantified in samples derived from lean and obese fat biopsy baseline
Primary Number of eosinophils in adipose tissue eosinophil number will be measured by flow cytometry in subcutaneous (superficial) adipose tissue baseline
Secondary Correlation between eosinophil content and body mass index (BMI) Measured as a linear regression between BMI (defined as the weight in Kg/height in square m; kg/m2) and eosinophil number in the fat baseline
See also
  Status Clinical Trial Phase
Recruiting NCT06052553 - A Study of TopSpin360 Training Device N/A
Completed NCT05511077 - Biomarkers of Oat Product Intake: The BiOAT Marker Study N/A
Recruiting NCT04632485 - Early Detection of Vascular Dysfunction Using Biomarkers From Lagrangian Carotid Strain Imaging
Completed NCT05931237 - Cranberry Flavan-3-ols Consumption and Gut Microbiota in Healthy Adults N/A
Completed NCT04527718 - Study of the Safety, Tolerability and Pharmacokinetics of 611 in Adult Healthy Volunteers Phase 1
Terminated NCT04556032 - Effects of Ergothioneine on Cognition, Mood, and Sleep in Healthy Adult Men and Women N/A
Completed NCT04998695 - Health Effects of Consuming Olive Pomace Oil N/A
Completed NCT04065295 - A Study to Test How Well Healthy Men Tolerate Different Doses of BI 1356225 Phase 1
Completed NCT04107441 - AX-8 Drug Safety, Tolerability and Plasma Levels in Healthy Subjects Phase 1
Completed NCT01442831 - Evaluate the Absorption, Metabolism, And Excretion Of Orally Administered [14C] TR 701 In Healthy Adult Male Subjects Phase 1
Terminated NCT05934942 - A Study in Healthy Women to Test Whether BI 1358894 Influences the Amount of a Contraceptive in the Blood Phase 1
Recruiting NCT05525845 - Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI N/A
Completed NCT05515328 - A Study in Healthy Men to Test How BI 685509 is Processed in the Body Phase 1
Completed NCT04967157 - Cognitive Effects of Citicoline on Attention in Healthy Men and Women N/A
Completed NCT05030857 - Drug-drug Interaction and Food-effect Study With GLPG4716 and Midazolam in Healthy Subjects Phase 1
Recruiting NCT04494269 - A Study to Evaluate Pharmacokinetics and Safety of Tegoprazan in Subjects With Hepatic Impairment and Healthy Controls Phase 1
Recruiting NCT04714294 - Evaluate the Safety, Tolerability and Pharmacokinetics Characteristics of HPP737 in Healthy Volunteers Phase 1
Completed NCT04539756 - Writing Activities and Emotions N/A
Recruiting NCT04098510 - Concentration of MitoQ in Human Skeletal Muscle N/A
Completed NCT03308110 - Bioavailability and Food Effect Study of Two Formulations of PF-06650833 Phase 1

External Links