Healthy Clinical Trial
Official title:
IL-6 Regulation of Substrate Metabolism and Influence of Obesity
The aim of the study is to investigate the effects of blocking IL-6 signaling with
tocilizumab on lipid, glucose and protein metabolism during rest and exercise in healthy and
obese humans.
Interleukin-6 is a molecule produced by a variety of cells and impacts on energy metabolism
during fasting and fed conditions. Systemic IL-6 levels are low but increase acutely in
response to fasting, exercise and infection, and also chronically in response to obesity and
other conditions of lowgrade inflammation.Our recent human intervention study showed that
IL-6 receptor blockade prevents exercise training from reducing visceral fat mass.
Whether IL-6 receptor blockade directly regulates lipolysis and/or lipid oxidation in humans
is however unclear. Therefore, this study will be performed to investigate the physiological
role of IL-6 on lipid, glucose and protein metabolism in humans.
The aim of the study is to assess changes in substrate kinetics, that is, lipolytic rate,
rate of appearance and disappearance of free fatty acids, fatty acid oxidation, glucose rate
of appearance and disappearance and protein synthesis and degradation during rest and
exercise with and without IL-6 receptor blockade. We will assess the acute effects of
blocking IL-6 as well as the long-term consequences of IL-6 receptor blockade on all the
above parameters.
Overall, we hypothesize that blocking IL-6 changes substrate kinetics. More specifically we
hypothesize that blocking IL-6 reduces the appearance of free fatty acids, reduces the
lipolytic rate and lipid oxidation. We hypothesize that the consequences of blocking IL-6
will be observed during resting and exercising conditions and both immediately and longterm
after IL-6 receptor blockade. We hypothesize that IL-6 receptor blockade results in an
increased respiratory exchange ratio (RER) and thus increased reliance on glucose as
substrate.
In this study 10 healthy males and 10 obese males will be included. Subjects will be infused
with saline on 2 of the study days and tocilizumab on 1 of the study days.
Isotope dilution techniques with [6,6-2H2]Glucose, [1,1,2,3,3-D5]glycerol,
K-[U-13C16]palmitate, L-[ring-D5]phenylalanine, L-[D2]tyrosine will be applied to assess
lipid, glucose and protein kinetics. Respiratory exchange ratio will be measured by indirect
calorimetry. The BORG scale will be used to assess the perceived exertion during exercise.
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