Biological Age in Health Promotion - Novel Health Technology

Healthy Clinical Trial

— BATE  

Official title:

Development of a New Biological Age Technology Applicable in Public Health Promotion Interventions.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03680768
• Other study ID #: Biological Age Technology
• Status: Completed
• Start date: October 9, 2018
• Est. completion date: December 20, 2019

Study information

• Verified date: February 2020
• Source: University of Copenhagen
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this cross-sectional study is to collect relevant molecular markers of aging and measures of physiological function. Together these biomarkers are used to develope a new Biological Age model, useful in health promotion interventions in the public health sector .

Description:

Study design: 100 participants representing the healthy danish working adult population. This study seek to include both men and women equally distributed in the range of 18-65 of age.

Data collection: After recruitment, participants need to attend once to the laboratory, overnight fasted and without having exercised for the previous 24 hours.

All analyse are done in investigators lab (Xlab) at the department of Biomedical Sciences, Copenhagen University. When analyzes are done, the results are used in algorithm developement in cooperation with Technical university Denmark.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: December 20, 2019
• Est. primary completion date: December 20, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Males and females interested in their personal health status

• Healthy males and females

Exclusion Criteria:

• Pregnancy

• Previous or current cardiovascular disease

• Use of medication that affects our measurements such as betablockers,statins or medication that affects the metabolism.

Related Conditions & MeSH terms

• Aging
• Healthy

Intervention

Other:
• Health Assessment
The protocol includes measurements of body composition, strength test, functional and fitness test as well as biochemical measurements from blood samples and AGEreader

Locations

Country	Name	City	State
Denmark	University of Copenhagen, Department of Biomedical Sciences	Copenhagen

Sponsors (2)

Lead Sponsor	Collaborator
University of Copenhagen	Technical University of Denmark

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Biological Age	A composite score of ones biological state (in years)	Day 1
Secondary	Fitness Level	VO2max - maximal oxygen consumption (ml/min/kg)	Day 0
Secondary	Strength	Hand grip, isometric quadriceps and biceps strength (Nm)	Day 0
Secondary	Sit to Stand test	Rise and sit from a chair as many times as possible during 1 minute (number og rises)	Day 0
Secondary	Central obesity	Waist to hip ratio is measured by dividing waist circumference with hip circumference in cm.	Day 0
Secondary	Weight	measured in kilograms	Day 0
Secondary	Height	measured in cm	Day 0
Secondary	Body composition	BMI (kg/m2) is calculated	Day 0
Secondary	Muscle mass	muscle mass(g) is assessed by dual energy x-ray absorptiometry (DXA) and bioimpedance	Day 0
Secondary	Fat mass	fat mass(g) is assessed by DXA and bioimpedance	Day 0
Secondary	Fat percentage	Fat%, is assessed by DXA and bioimpedance	Day 0
Secondary	Lipid profile	HighDensityLipoprotein (mmol/L), LowDensityLipoprofile (mmol/L), TriGlycerides (mmol/L), FreeFattyAcids (mmol/L) and Glycerol (mmol/L) is measured in a blood sample.	Day 0
Secondary	Hormones	Sex hormones: testosteron and estradiol (nmol/L) and InsulinGrowthFactor-1 (nmol/L) and Insulin (µU/ml) ais analysed from blood samples	Day 0
Secondary	Inflammatory profile	C-reactive protein mg/L, soluble urokinase plasminogen activating receptor ng/ml, InterLeukin 6,8 and 10 (pg/mL), tumor necrosis factor (pg/mL), Leptin and Adiponectin (ng/ml) is analysed from blood samples	Day 0
Secondary	Levels of glycated protein and lipids as a result of exposure of excess sugars	advanced glycation endproducts (AGE) measured in the skin	Day 0
Secondary	Color passport photography	Profile picture taken to assess perceived age	Day 0
Secondary	Respirometry	forced vital capacity and forced expiratory volume at one second(L)	Day 0
Secondary	Blood Pressure	Systolic and Diastolic blood pressure (mmHg)	Day 0
Secondary	Blood glucose	HbA1c and fasting glucose (mmol/L) measured from blood sample	Day 0
Secondary	Blood profile	Haematocrit and Haemoglobin (mmol/L) measured in a blood sample	Day 0
Secondary	Aging biomarker	Chemokines Eotaxin (CCL11) analysed from blood samples	Day 0
Secondary	Youth biomarker	Growth Differential Factor (GDF-11) analysed from blood samples	Day 0