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Ketone Plasma Kinetics After Oral Intake Of Different MCT

Healthy Clinical Trial

Official title:
Ketone Plasma Kinetics After Oral Intake Of Different MCT Formulae

Clinical Trial Summary

This research project is aimed at identifying the MCT formulation matrixes that provide the highest ketoindex values and extended half-life, as well as to provide an initial evaluation of the GI tolerability of the various formula. For comparison, ketones salts and esters (food grade) will be also evaluated.

Clinical Trial Description

Monocentric, open, randomized, controlled research project. The global research project will include several testing cycles as described in the figure 1. In each cycle, several research products (up to 4) will be tested on up to 20 participants in a partial or full cross-over design. Once cycle 1 is completed, blood parameters will be analysed and ketoindex will be calculated as area under the curve (AUC) of total ketones (BHB + AcA) over 4h / quantity of ingested MCTs in g. Based on ketoindex and ketones Thalf (T1/2: time to reach half of AUC-infinite of total ketones) values, new products will be developed for cycle 2. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03603782
Study type Interventional
Source Société des Produits Nestlé (SPN)
Contact
Status Completed
Phase N/A
Start date June 4, 2018
Completion date December 31, 2023
View Details
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