Healthy Clinical Trial
Official title:
Effects of Microencapsulated Sublingual Glycine (Bidicin) on Cognitive Performance in Healthy Men After an Acute Stressor - a Randomized, Partly Double-blind Placebo-controlled Clinical Trial
The aim of this study is to assess whether intake of Glycine (MSG) leads to an increase of cognitive performance after an acute stressor compared to placebo. One group will receive verum, one group placebo and one group will not receive any intervention. Cognitive testing will be performed in connection with the Trier Social Stress Test (TSST).
Stress can enhance or impair memory performances depending on the timing of the stressor and
the timing of the memory processes in relation to the stressor. If stress occurs directly
before or during the retrieval of information, the performance is impaired. Decreased
performances using an acute stressor were also observed for other domains of cognitive
functioning like working memory, interference control, cognitive flexibility and attention
tasks.
Glycine, the simplest of the amino acids, is an essential component of important biological
molecules, a key substance in many metabolic reactions, the major inhibitory neurotransmitter
in the spinal cord and brain stem, and an anti-inflammatory, cytoprotective, and immune
modulating substance. Studies have found positive effects of Glycine on episodic memory
retrieval and in a word retrieval task.
To assess the effect of Glycine (MSG) on cognitive performance after an acute stressor,
subjects perform baseline cognitive testing before intake of investigational products
(Glycine (MSG), placebo or nothing) and participation in a stress test (Trier Social Stress
Test - TSST). After the TSST stress-induced changes in cognitive performance are assessed. A
second treatment intake takes place between the first and the remaining cognitive tests.
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