Healthy Clinical Trial - Exercise Regulation of Human Adipose Tissue

Status Active, not recruiting

Clinical Trial Summary

The purpose of this study is to determine whether exercise training leads to changes in the white adipose tissue that are beneficial to the body's regulation of sugar and body weight.

Clinical Trial Description

The prevalence of obesity and type 2 diabetes in the United States and worldwide has risen dramatically over the last few decades, resulting in an enormous need for new therapies to treat these conditions. The discovery that beiging of subcutaneous white adipose tissue may increase energy expenditure has led to tremendous interest in beige cells as a potential treatment for diabetes and obesity. An established treatment for type 2 diabetes and obesity is endurance exercise training. Exercise training can improve systemic homeostasis, and although adaptations to skeletal muscle play a critical role in these effects, the underlying mechanisms are not fully understood. Moreover, the contributions of other tissues in these beneficial effects of exercise on metabolism have not been intensively investigated. The study team hypothesizes that exercise training results in fundamental changes to white adipose tissue, including beiging, and these adaptations play an important role in the effects of exercise training to improve metabolic homeostasis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03133156
Study type	Interventional
Source	Joslin Diabetes Center
Contact
Status	Active, not recruiting
Phase	N/A
Start date	June 15, 2017
Completion date	January 1, 2026

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