Healthy Clinical Trial
Official title:
Metabolic Intervention in the Right Ventricle in Pulmonary Arterial Hypertension
The purpose of this study is to use non-invasive imaging to determine the metabolic phenotype of the right ventricle in patients with pulmonary arterial hypertension across a spectrum of disease severity.
Current medical therapy for pulmonary arterial hypertension (PAH) is aimed at reducing
pulmonary vascular resistance (PVR) but not ameliorating right ventricular (RV) failure, the
major cause of death. There are no RV-specific therapies currently available for PAH, in part
because the pathophysiology of RV failure is poorly understood.
The investigators hypothesize that the RV in PAH develops a distinct metabolic pattern
characterized by increased glycolysis, impaired oxidative metabolism and lipid deposition,
which are associated with RV failure.
Specific Aim 1. To test the hypothesis that the RV in human PAH exhibits lipid deposition,
increased glycolysis and impaired fatty acid oxidation. The investigators will measure RV
oxidative metabolism and glycolysis in PAH patients and controls using positron emission
tomography 11C acetate and [18F]fluoro-deoxy-D-glucose imaging and measure myocardial lipid
accumulation using magnetic resonance spectroscopy imaging.
Specific Aim 2. To test the hypothesis that an abnormal RV metabolic profile is associated
with RV dysfunction and reduced exercise capacity in PAH. PET and MRS findings will be
correlated with RV function, patient exercise capacity and a blood metabolic profile.
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