Healthy Clinical Trial
— MitoWomenOfficial title:
Mitochondrial Function in Circulating Cells and Muscle Tissue
NCT number | NCT02700698 |
Other study ID # | 205139 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | September 2016 |
Est. completion date | May 1, 2018 |
Verified date | October 2021 |
Source | University of Arkansas |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The main goal of this project is to determine whether mitochondrial function in circulating cells is related to that measured in the muscle fibers of the same subjects.
Status | Completed |
Enrollment | 35 |
Est. completion date | May 1, 2018 |
Est. primary completion date | April 26, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 25 Years to 35 Years |
Eligibility | Inclusion Criteria: - Women - 25-35 years of age - Either healthy lean (BMI<25) or insulin resistant and obese (BMI >30) Exclusion Criteria: - Medication that can affect study outcomes, as determined by the principal investigator, including anti-diabetic medication - Chronic diseases, acute inflammation, chronic renal failure (glomerular filtration rate <45), or heart problems |
Country | Name | City | State |
---|---|---|---|
United States | Arkansas Children's Nutrition Center | Little Rock | Arkansas |
United States | UAMS | Little Rock | Arkansas |
Lead Sponsor | Collaborator |
---|---|
University of Arkansas | Arkansas Children's Hospital Research Institute |
United States,
Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Børsheim E. A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E5 — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Mitochondrial Function in Circulating Cells and Muscle Tissue in Young Women | Skeletal muscle (m.vastus lateralis) and peripheral blood mononuclear cell (PBMC) mitochondrial respiration were determined in response to substrate inhibitor coupling protocols using high resolution respirometry.
From this, mitochondrial respiration in leak and coupled states, and reserve respiratory capacity were determined in mitochondria from skeletal muscle and from PBMCs. It was determined whether mitochondrial function in circulating cells is related to that measured in the muscle tissue of the same subjects. |
During the visit, approximately 0.5 days |
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