Healthy Clinical Trial - Coffee, Exercise, & Oxidative Stress

Status Completed

Clinical Trial Summary

Clinical Trial Description

Coffee is one of the most widely consumed beverages. It contains polyphenols (chlorogenic acids) and bioavailability of these bioactive compounds is now somewhat well understood. However, even if chlorogenic acids are known to be antioxidants in the cup, reliable evidence remains to be observed in vivo.

After medical examination and approval, subjects will undergo 2 periods of 21 days. The first 7 days will consist of a dietary restriction to lower the polyphenols intake. Then subjects will drink at random one of the three treatments for 14 days (4 cups/day). Blood and urine samples will be collected throughout the study to evaluate in vivo effects on oxidative biomarkers. Furthermore, at day 21, subjects will undergo a physical regimen to increase acutely and transiently their oxidative damage. Blood and urine samples collected throughout this challenge will allow us to evaluate the effect of coffee intake in reducing oxidative damage created by exercise compared to placebo. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor)

Related Conditions & MeSH terms

Healthy

Clinical Trial Details

NCT number	NCT01832701
Study type	Interventional
Source	Nestlé
Contact
Status	Completed
Phase	N/A
Start date	March 2012
Completion date	June 2013

View Details

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Coffee, Exercise, and Oxidative Stress

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms