Healthy Clinical Trial
Official title:
Effects of Transcranial DC Stimulation Coupled With Constraint Induced Movement Therapy on Motor Function in Stroke Patients
The purpose of this study is to determine whether noninvasive brain stimulation associated
with motor learning offers an additional benefit than motor learning alone in patients with
stroke.
The investigators hypothesis is that active transcranial direct current stimulation (tDCS)
combined with constraint induced movement therapy (CIMT) will induce a greater motor function
improvement as compared with sham tDCS combined with CIMT.
In this 3 experiments study we will evaluate the effect of tDCS and constraint induced
movement therapy (CIMT) in stroke patients (exp 1) as well as in healthy subjects (control
population - exp 2). Finally we will investigate the effect of tACS - transcranial
alternating current stimulation - as an alternative to tDCS, on motor function in healthy
subjects (exp 3). The two experiments on tDCS are parallels (exp 1 & 2), while the experiment
on tACS uses a crossover design (exp 3).
For stroke patients (Exp1), our primary outcome measure is a clinical scale (Jebsen-Taylor
Hand Function Test), while for healthy subjects (Exp 2) we investigate the effect of tDCS and
CIMIT on cortico-spinal excitability using TMS - transcranial magnetic stimulation. Finally,
for the third experiment using tACS, our primary outcome is cortical oscillation, as measured
by EEG - electroencephalogram.
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