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NCT00853775 Clinical Trial

Family Research Study: Metabolism of Fats and Proteins in Specific Ethnic Groups

Healthy Clinical Trial

Official title:
Regulation of Lipoprotein(a) Metabolism in Humans With Reference to Ethnicity

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00853775
Other study ID # 200816533
Secondary ID 2R01HL062705-05A
Status Completed
Phase N/A
First received February 25, 2009
Last updated May 25, 2017
Start date February 2009
Est. completion date December 2012

Study information
Verified date May 2017
Source University of California, Davis
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study is to determine whether lipoprotein(a), also called Lp(a), is a risk factor for cardiovascular (heart) disease. Lipoproteins are tiny particles that circulate in the blood. They contain cholesterol, fat, and protein in varying amounts depending on the body's need. Higher levels of lipoproteins in the blood can cause an increased risk of heart disease.

The investigators believe that by studying the Lp(a) lipoprotein in Caucasians and African Americans, the investigators can assess for genetic variation factors related to cardiovascular (heart) disease. The investigators will be looking at 100 African-American families and 100 Caucasian families to confirm whether a higher Lp(a) level is an indicator of a higher risk for heart disease.

Description:

During the study visit the research staff will ask about the medical history, perform a brief physical exam, and draw approximately 4 teaspoons of blood of each family member.

Recruitment information / eligibility
Status Completed
Enrollment 325
Est. completion date December 2012
Est. primary completion date May 2012
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 6 Years and older
Eligibility Inclusion Criteria:

- Of Caucasian or African descent

- Families must have 2 natural/biological parents and 2 natural/biological offspring

- 6 years old or older

Exclusion Criteria:

- Races other than African American or Caucasian

- Families without 2 natural/biological parents and 2 natural/biological offspring

- younger that 6 years old

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• No intervention, observational study

Locations
Country Name City State
United States UC Davis CTSC Clinical Research Center (CCRC) at Veterans Affair Medical Center Mather California

Sponsors (3)
Lead Sponsor Collaborator
University of California, Davis National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Genetic variation of Lp(a) levels in each group five years
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