Healthy Clinical Trial
Official title:
Plasma Catecholamine Kinetics
Brain and nerve cells communicate with each other by releasing and picking up chemicals
called neurotransmitters. Norepinephrine is a neurotransmitter used by part of the nervous
system activated during stress called the sympathetic nervous system. The sympathetic
nervous system is involved with regulating blood pressure and pulse rate. Researchers
believe the level norepinephrine in the blood can be used to measure activity of the
sympathetic nervous system.
This study is designed to answer important questions about rates of release of
norepinephrine into the blood stream, removal of released norepinephrine, and the
sympathetic nervous system response to stress.
Researchers will attempt to measure levels of norepinephrine and activity of the sympathetic
nervous system in patients with high blood pressure, normal patients with family histories
of high blood pressure, patients taking drugs that can effect levels of norepinephrine, and
patients with diseases or conditions directly affecting the sympathetic nervous system.
Status | Completed |
Enrollment | 50 |
Est. completion date | September 2002 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A and older |
Eligibility |
Must be greater than or equal to 18 years of age. Must not be pregnant or lactating. |
N/A
Country | Name | City | State |
---|---|---|---|
United States | National Institute of Neurological Disorders and Stroke (NINDS) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Goldstein DS, Eisenhofer G, Stull R, Folio CJ, Keiser HR, Kopin IJ. Plasma dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans. J Clin Invest. 1988 Jan;81(1):213-20. — View Citation
Goldstein DS, Horwitz D, Keiser HR, Polinsky RJ, Kopin IJ. Plasma l-[3H]norepinephrine, d-[14C]norepinephrine, and d,l-[3H]isoproterenol kinetics in essential hypertension. J Clin Invest. 1983 Nov;72(5):1748-58. — View Citation
Rea RF, Eckberg DL, Fritsch JM, Goldstein DS. Relation of plasma norepinephrine and sympathetic traffic during hypotension in humans. Am J Physiol. 1990 Apr;258(4 Pt 2):R982-6. — View Citation
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