Healthy Clinical Trial
Official title:
Blood Sampling for Neurochemical and Genetic Testing
This study involves sampling blood from both normal volunteers and patients with diseases
known or suspected to involve body chemicals called catecholamines. The blood will be used
to establish normal values for plasma levels of catecholamines and related neurochemicals;
to test for abnormal neurochemical patterns in patients; and to establish a "bank" of DNA
from normal volunteers and from patients to be used in future studies about possible
alterations of catecholamine-related genes.
Study participants will report to NIH after fasting overnight except for water or
noncaloric, noncaffeinated beverages. They must not have taken Tylenol for at least 5 days.
Blood will then be drawn. DNA will be extracted and stored in the freezer for future
studies.
Status | Completed |
Enrollment | 500 |
Est. completion date | March 2004 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A and older |
Eligibility |
INCLUSION CRITERIA: The subjects are healthy normal volunteers or patients with dysautonomia, pheochromocytoma, hypertension, or neurogenetic diseases involving catecholaminergic systems. Children of any age above 4 years may participate. In the case of minors, consent is obtained from an adult who is legally responsible for the subject. EXCLUSION CRITERIA: Subjects in whom anatomic or technical factors preclude insertion of an arm intravenous (i.v.) catheter are excluded. Normal volunteers taking any prescribed medication are excluded. Normal volunteers who smoke cigarettes or consume alcohol daily are excluded. |
N/A
Country | Name | City | State |
---|---|---|---|
United States | National Institute of Neurological Disorders and Stroke (NINDS) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Goldstein DS, Lenders JW, Kaler SG, Eisenhofer G. Catecholamine phenotyping: clues to the diagnosis, treatment, and pathophysiology of neurogenetic disorders. J Neurochem. 1996 Nov;67(5):1781-90. Review. — View Citation
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