Head and Neck Neoplasms Clinical Trial
Official title:
A Multicenter Phase II Trial of Docetaxel Combined With Cisplatin (CDDP) as a Neo-Adjuvant Chemotherapy in Patients With Loco Regionally Advanced Undifferentiated Carcinoma of Nasopharyngeal Type (UCNT)
Primary Objective:
To estimate the overall response rate after neo-adjuvant chemotherapy of Docetaxel 75 mg/m2
in combination with Cisplatin 75 mg/m2 given for 3 cycles, and followed by conventional
radiotherapy in UCNT.
Secondary Objectives:
To evaluate:
- The radiological response after chemotherapy and radiotherapy
- The pathological response after chemotherapy by cavum biopsy
To estimate:
- The duration of overall response
- The time to progression (T.T.P)
To analyze:
- The overall survival
- The safety profile
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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