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Glaucoma clinical trials

View clinical trials related to Glaucoma.

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NCT ID: NCT05389267 Active, not recruiting - Glaucoma Clinical Trials

Safety Assessment of T4090 Eye Drops in Ocular Hypertensive or Glaucomatous Patients.

Start date: July 5, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

The study purpose is to evaluate the safety of T4090.

NCT ID: NCT05335122 Active, not recruiting - Ocular Hypertension Clinical Trials

A Study to Evaluate the Efficacy and Safety of OTX-TIC (Travoprost) Intracameral Implant for Patients With Open-angle Glaucoma (OAG) or Ocular Hypertension (OHT)

Start date: March 16, 2022
Phase: Phase 2
Study type: Interventional

To assess efficacy, and safety of a single sustained release dose of the OTX-TIC drug product (2 travoprost dose strengths) in subjects with Open Angle Glaucoma (OAG) or Ocular Hypertension (OHT)

NCT ID: NCT05278299 Active, not recruiting - POAG Clinical Trials

Asia Glaucoma Registry

Start date: October 1, 2021
Phase:
Study type: Observational

Glaucoma remains a leading cause for irreversible visual impairment and blindness worldwide and it disproportionately affects people residing in Asia, there is a need to ensure optimal management of the disease in patients with glaucoma. The ability to estimate the rates of structural and functional loss in patients with glaucoma will enable clinicians to identify those with rapidly deteriorating conditions or those at-risk, and to therefore provide timely treatment to these patients. Despite this, there are currently several challenges in identifying rapid-progressors in glaucoma, including lack of consensus on the definition of 'rapid' progression and what rates of change of visual field (VF) encompass clinically significant deterioration relevant to the patients. As such, the Asia Glaucoma Registry is intended to collect data to advance the understanding of glaucoma and its progression in Asia and to understand the management patterns of glaucoma in Asia. The Registry will also provide research data for future collaborative scientific research projects.

NCT ID: NCT05236439 Active, not recruiting - Clinical trials for Glaucoma, Open-Angle

Study of a Cilioscleral Interposition Device (CID) SV22 in Patients With Primary Open Angle Glaucoma

SAFARI 3
Start date: May 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the safety and effectiveness of implanting a new version of an interposition supraciliary implant (SV22) as a stand-alone therapy for lowering intraocular pressure (IOP) in patients with primary open angle glaucoma (POAG) and primary narrow angle glaucoma (PNAG) who have failed at least one class of topical medical therapy

NCT ID: NCT05160805 Active, not recruiting - Open Angle Glaucoma Clinical Trials

A Phase 1b Study of ONL1204 Ophthalmic Solution in Patients With Progressing Open Angle Glaucoma

Start date: May 2, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to demonstrate the safety and tolerability of ONL1204 Ophthalmic Solution in patients with progressing open angle glaucoma. ONL1204 Ophthalmic Solution is a first-in-class inhibitor of fragment apoptosis stimulator (Fas) receptor-mediated cell death that has demonstrated protection of multiple retinal cell types in numerous preclinical models of retinal disease. Apoptosis of retinal ganglion cells is associated with progressive glaucoma. Nonclinical data on ONL1204 Ophthalmic Solution suggest that ONL1204 Ophthalmic Solution may inhibit the cell death pathways in these cells.

NCT ID: NCT05159817 Active, not recruiting - Clinical trials for Glaucoma, Open-Angle

Study of an Interposition Supraciliary Implant in Patients With Open Angle Glaucoma

SAFARI FU
Start date: December 15, 2021
Phase:
Study type: Observational

The purpose of this study is to prolong observational follow-up up to 36 months of patients already implanted with a novel interposition supraciliary implant.

NCT ID: NCT05130554 Active, not recruiting - Surgery Clinical Trials

XEN45 in the Treatment of Chinese Patients With Primary Open-angle Glaucoma

Start date: November 7, 2021
Phase: N/A
Study type: Interventional

Glaucoma is the second most common blindness disease in the world, second only to cataracts. The current treatment of glaucoma is mainly to reduce intraocular pressure.At present, two commonly used surgical methods are trabeculectomy and implantation of drainage valve. These methods are superior to drug treatment in reducing intraocular pressure, but the effect duration of these two methods is not long, and there may be serious complications and failure. Compared with traditional glaucoma surgery, MIGS may have better safety.The XEN45 gel implant is a collagen tube with a length of 6 mm and a diameter of 45 µm, which creates a new channel for drainage of aqueous humor by connecting the anterior chamber and the subconjunctival space. The implant is composed of porcine gelatin cross-linked with glutaraldehyde, and has good biocompatibility and tolerance. Therefore, after the advent of XEN45 products, more and more studies have shown that this treatment has excellent safety and effectiveness in reducing intraocular pressure in patients with open-angle glaucoma. Considering that the XEN45 gel stent has been in the market for a relatively short time, we conducted this prospective study to investigate the effect of XEN45 surgery in the treatment of primary open-angle glaucoma, in order to support ophthalmologists in formulating the best surgical plan for patients. The promotion of this surgical method.

NCT ID: NCT05127551 Active, not recruiting - Glaucoma Clinical Trials

Clinical Study of Glaukos® Trabecular Micro-Bypass System Model iS3 Infinite Vs. Competitor

Start date: November 27, 2021
Phase: N/A
Study type: Interventional

A study of the iStent Infinite product in the treatment of open-angle glaucoma vs competitor

NCT ID: NCT05035394 Active, not recruiting - Cataract Clinical Trials

Swedish Microinvasive Glaucoma Surgery Study (SMIGS)

SMIGS
Start date: September 16, 2021
Phase: N/A
Study type: Interventional

The purpose of the study is to investigate the efficacy of Cataract Surgery as stand-alone compared to Cataract Surgery in combination with Kahook Dual Blade Glide goniotomy (KDB) or iStent Inject W Trabecular Microbypass Stent (Istent) in eyes with Open-angle glaucoma.

NCT ID: NCT04899063 Active, not recruiting - Clinical trials for Glaucoma, Primary Open Angle

Excimer Laser Trabeculostomy Glaucoma Treatment Study

ELTGTS
Start date: May 10, 2021
Phase: N/A
Study type: Interventional

Evaluation of the safety and effectiveness of the ELIOS System procedure to reduce intraocular pressure (IOP) in adult subjects with mild to moderate primary open-angle glaucoma (POAG) undergoing cataract surgery