Association Study of Gene Polymorphisms With Cardiac Performance

Status Recruiting

Clinical Trial Summary

The purpose of this study is to determine whether polymorphisms in G protein subunits, namely Galphas and Galphaq, are associated with altered cardiac performance in heart failure patients.

Clinical Trial Description

G Protein pathways plays a pivotal role in mediating positive inotropy and cardiac hypertrophy by transducing signals of neurohormones in cardiomyocytes. Single nucleotide polymorphisms (SNPs) in the G protein subunits Galphas and Galphaq have been shown to result in altered protein expression. We now want to examine whether G Protein polymorphisms alter NYHA functional class, and hemodynamic variables in patients with coronary artery disease scheduled for coronary artery bypass grafting . ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00730899
Study type	Observational
Source	University Hospital, Essen
Contact	Ulrich H Frey, MD
Phone	+49201723
Email	ulrich.frey@uk-essen.de
Status	Recruiting
Phase	N/A
Start date	May 2008
Completion date	June 2011

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