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Frailty clinical trials

View clinical trials related to Frailty.

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NCT ID: NCT06268132 Recruiting - Aging Clinical Trials

Longevity in Russia

Start date: December 25, 2019
Phase:
Study type: Observational

This is an observational cohort study of long-living adults (participants aged 90 and above) from the Central Federal District of Russia. The study seeks to determine the genetic and cellular and molecular determinants of healthy longevity and to assess the impact of lifestyle and socioeconomic and environmental factors on healthy longevity. The study is expected to result in the development of a panel of markers of healthy longevity and/or a model of healthy aging based on the analysis of all factors under consideration.

NCT ID: NCT06267378 Recruiting - Bowel Cancer Clinical Trials

Assessing Frailty and Its Impacts on Patients Facing Major GI Surgery

Start date: August 30, 2023
Phase:
Study type: Observational

The study team will look at 3 new tests that will make it easier to measure frailty in patients awaiting surgery for cancer and compare them against standard clinical measures of frailty in a pilot study. The expected outcome is that evidence will be collated in order to apply for a major grant to look at improving the care of frail patients with cancer in the future.

NCT ID: NCT06262815 Recruiting - Frailty Clinical Trials

The Utility of Treatment With Nasogastric Tube Placement for Small Bowel Obstruction

NGTUBE-OBS
Start date: January 1, 2024
Phase:
Study type: Observational

Small bowel obstruction (SBO) occurs when the normal movements of the small bowel is obstructed, most commonly due to adhesion related to previous abdominal surgery. This may cause strangulation of the small bowel with reduced blood flow which is a surgical emergency requiring prompt treatment in the operating room. If there are no signs of strangulation or ischemia of the bowel at the time of diagnosis, international guidelines recommend initial treatment with intravenous fluids and nasogastric tube placement. However, there is emerging debate regarding non-selective treatment with nasogastric tube placement in patients with SBO. This management started around 1930 as a means to reduce pain in patients with SBO, in conjunction with other additions to management, like intravenous fluids. However the effect and utility of routine nasogastric tube placement have not been prospectively evaluated. There are a total of three retrospective observational studies in the past decade with a total of 759 patients where 292 (36%) were managed without a nasogastric tube. There was no difference in the rates of conservative treatment failure (requiring surgery), complications (vomiting, pneumonia) or mortality between patients receiving a nasogastric tube and those who didn't. However, the retrospective design of these studies limits their validity. Furthermore, nasogastric tube placement has been shown to be one of the more painful interventions patients may experience in-hospital. This calls into question the patient benefit of routine nasogastric tube placement in patients with SBO and further studies are needed to discern the utility of this intervention. Definitive treatment for SBO is surgical adhesiolysis but there is debate regarding the timing of surgery, particularly in older adults. A large proportion of patients may be managed conservatively with oral contrast and repeated radiological evaluation and the obstruction will resolve in many patients within 24 to 48 hours. This timeframe is dependent on factors related to the disease itself as well as patient related factors like previous surgery and comorbidities. Older patients are at high risk for complications but current available data is insufficient to inform practice in this population. Frailty, a state of increased vulnerability and susceptibility to adverse events, has been shown to be an independent prognosticator in older adults in the Emergency Department(ED) and suggested as a potential measure to risk stratify older adults with SBO. However to the authors knowledge there is no available data on frailty in older adults with SBO and only one prospective observational trial looking at older adults with SBO. Despite SBO being one of the most common surgical emergencies in older adults. To investigate the potential benefit of nasogastric tube placement in patients with SBO and the ability of frailty to prognosticate outcomes in older adults better evidence is needed.

NCT ID: NCT06247358 Recruiting - Physical Disability Clinical Trials

Frailty, Physical Capacity and Lung Function in Postoperative Cardiac Surgery Patients

Start date: February 16, 2024
Phase:
Study type: Observational

The goal of this observational and prospective study is to investigate changes in physical performance, lung function, and respiratory and peripheral muscle strength in patients during the postoperative period following coronary artery bypass grafting (CABG) and valve replacement surgery..

NCT ID: NCT06247189 Not yet recruiting - Multiple Myeloma Clinical Trials

ICOPE Program Feasibility in the Management of Myeloma Patients

Onco-ICOPE
Start date: September 1, 2024
Phase: N/A
Study type: Interventional

This project proposes to adapt monthly the existing ICOPE (Integrated Care for Older People) MONITOR program for elderly myeloma patients. This adaptation aims to detect earlier functional decline and prevent loss of autonomy.

NCT ID: NCT06244199 Not yet recruiting - Clinical trials for Cardiovascular Diseases

Transition to Cardiac Rehabilitation (T2CR) to Address Barriers of Multimorbidity and Frailty

T2CR
Start date: July 15, 2024
Phase: Phase 2
Study type: Interventional

Cardiac rehabilitation (CR) is a secondary prevention program for patients with cardiovascular disease (CVD). It is especially valuable as CVD increasingly occurs in combination with comorbidity, frailty, and complexities of care that predispose patients to functional decline, disability, and high costs. Still, few Veterans participate in CR, in part because of the difficult logistics to attend. Promising Practice home-based CR (HBCR) was developed to increase CR participation, but many Veterans remain too limited by comorbidity and frailty for participation. A Transition to CR (T2CR) intervention is a face-to-face program that fosters vital skills, education, insights, motivation, and patient-provider relationships conducive to successful HBCR thereafter. This study compares Veterans eligible for CR who are randomized to T2CR intervention versus usual care. Differences in functional capacity, HBCR participation, and healthy days at home are compared over one year. Patients' experiences and providers' perspectives of barriers and facilitators to T2CR are also compared.

NCT ID: NCT06231576 Not yet recruiting - Surgery Clinical Trials

Digital Home-Based Prehabilitation Before Surgery

dHOPE
Start date: February 1, 2024
Phase: N/A
Study type: Interventional

This clinical trial compares two different prehabilitation programs, with no organized prehabilitation, prior to major colorectal cancer surgery. The prehabilitation programs include intensive and coached physical exercise and optimized nutritional intake coupled with smoking cessation, physiological support and correction of poly-pharmacy.

NCT ID: NCT06225271 Not yet recruiting - Frailty Clinical Trials

Effects of the Combined Intervention of Exercise, Fruit, and Vitamin Supplementation on Frailty in Older Adults

EFVF
Start date: February 25, 2024
Phase: N/A
Study type: Interventional

The goal of this cohort-based cluster-randomized controlled trial is to investigate the effect of the combined intervention of exercise, fruit, and vitamin supplementation on frailty among older adults. Older individuals aged 65~80 years old with low physical activity levels and low fruit intake will be recruited. 14 clusters will be randomized into 2 arms with 1:1 ratio. Participants in the intervention arm will receive the combined intervention of physical activity, fruit, and vitamin supplementation 3 times a week for 2 months (the 1st and 6th months). They will also be given group interventions, such as self-management group activity or health education, at least once a week. Participants in the control arm will not receive any intervention.

NCT ID: NCT06224556 Not yet recruiting - Older People Clinical Trials

A Personalized Prevention Program (PPP) Based on the Comprehensive Geriatric Assessment (CGA) for the Prevention of Multidimensional Frailty Related to Non-communicable Chronic Diseases (NCDs) in Older People

PrimaCare_P3
Start date: February 1, 2024
Phase: N/A
Study type: Interventional

- Non-Communicable Diseases (NCDs) can accelerated the aging process and increase the frailty condition - The Comprehensive Geriatric Assessment (CGA) is the gold standard in the geriatric clinical context - Recently, in Italy the first Guidelines about the CGA in different settings for older people has been pubblicated - The CGA can identify older people at high risk of frailty who can benefit from a personalized prevention program - No studies has been investigated the effects of a personalized prevention program (PPP) based on the CGA in a primary care setting - The main hypothesis is that the CGA assessment can result in personalized prevention programs for older subjects in primary care settings with an effect in reducing the hospitalization rate and can be related to the biological paramters in NCDs

NCT ID: NCT06218121 Recruiting - Depression Clinical Trials

Update on the Detection of Frailty in the Older Adult

Start date: April 20, 2024
Phase:
Study type: Observational [Patient Registry]

The main objective is to update the diagnostic assessment of frailty by correlating several variables with the ultrasound image of the frail elderly patient. Secondarily, the investigators intend to collect and analyze data on functional capacity and quality of life variables on the evolution of musculoskeletal symptoms, as well as on pain and psychological variables. Similarly, it is intended to make a record of different profiles and subtypes of frail older adult patients to be stored in Big Data in order to establish therapeutic intervention plans that allow both the evaluation and treatment of patients.