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Fractures, Stress clinical trials

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NCT ID: NCT05912998 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Comparative Study Between Autologous Adipose Tissue Graft Versus Microfracture for Treatment of Articular Cartilage Defects

Start date: June 15, 2023
Phase: N/A
Study type: Interventional

Knee arthroscopy using standard portals will be performed in three groups. Complete evaluation of all intra -articular structures will be performed followed by accurate localization of the cartilage defect and measurement of its dimensions. The cartilage lesion grading according to the International Cartilage Repair Society system (ICRS). The patients assigned for the first group will have Liposuction through a minor 1 cm incision on the abdomen to obtain adequate amount of emulsified adipose tissues (50 - 60 cc). Autologous adipose tissue will be mixed with autologous hyaline cartilage obtained from non-weight bearing areas of the knee in prepared mold. The graft will be mixed with fibrin glue and left to solidify a little. After obtaining the fashioned graft from the mold it will be fixed in to the defect site by fibrin glue through mini open approach and stability of the implant fitted in the site will evaluated by gentle cycling of the joint. During the graft preparation, a high tibial osteotomy will be performed. Patients assigned for the second group will have microfracture in association with open wedge high tibial osteotomy. Patients assigned for the third group will have open wedge high tibial osteotomy. Standard titanium T locked plate will be used to fix the open wedge osteotomy in the three groups.

NCT ID: NCT05899686 Completed - Stress Reaction Clinical Trials

Effect of Location of Tetanic Stimuli on Photoplethysmogram Under General Anesthesia

Start date: January 27, 2016
Phase: N/A
Study type: Interventional

The effect of the location of tetanic stimulus on photoplethysmography signals will be studied in patients under general anesthesia.

NCT ID: NCT05899127 Recruiting - Stress Reaction Clinical Trials

Relationship Between Lidocaine and Serum Orphanin FQ (N/OFQ)

Start date: July 22, 2023
Phase: Phase 4
Study type: Interventional

The intravenous injection of lidocaine during the perioperative period has been widely used in various types of surgeries. Its clinical effect includes reducing stress response during anesthesia, decreasing pain and opioid consumption, lowering the incidence of postoperative nausea, vomiting, cognitive dysfunction, and reducing the injection pain of propofol. However, despite the positive impact of lidocaine on surgical patients, its mechanism of action remains unclear. Serum N/OFQ is a neurotransmitter that plays an important role in regulating pain and emotion. Therefore, this study aims to explore the effects of perioperative intravenous injection of lidocaine on stress responses in surgical patients, as well as its mechanism of action, and whether Serum N/OFQ participates in this process.

NCT ID: NCT05876897 Recruiting - Stress Fracture Clinical Trials

US vs MRI for Stress Injuries

Start date: February 3, 2021
Phase:
Study type: Observational

The primary purpose of this study is to determine whether or not there is a correlation between MRI and ultrasound for the diagnosis of lower limb stress injuries. Patients that are seen at the University of Iowa Sports Medicine Center with a suspected diagnosis of a lower limb stress injury will be recruited. These patients will undergo a diagnostic ultrasound of the affected region prior to undergoing an MRI of that region. Then, the ultrasound findings will be compared to the MRI findings to determine if a correlation exists.

NCT ID: NCT05868798 Completed - Sleep Clinical Trials

Can Ammonium Inhalants Maintain Performance in Sleep Deprived Soldiers?

Start date: October 1, 2020
Phase: Phase 1
Study type: Interventional

This study aims to examine the effectiveness of ammonia inhalants in countering the effects of total sleep deprivation on cognitive and physical performance tests relevant to military personnel.

NCT ID: NCT05843864 Recruiting - Clinical trials for Stress Fracture of Tibia

Photobiomodulation Therapy for the Treatment of Lower Extremity Stress Fractures in a Military Training Setting

PM12
Start date: June 7, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to compare photobiomodulation therapy (PBMT) in addition to standard of care in the treatment of tibial and metatarsal bone stress injuries in a military training setting. Participants will all receive usual care and also be randomized to either active or sham photobiomodulation therapy. Effectiveness will be assessed based on time to return to duty and measures of pain and function. - Participants will receive care for a maximum of 6 weeks. - Participants will have follow-up through 4 months (or graduation/dismissal from training, whichever comes first).

NCT ID: NCT05821270 Active, not recruiting - Clinical trials for Military Operational Stress Reaction

Effects of Ashtanga-Vinyasa Yoga Supta on Portuguese Airforce Military Pilots Performance

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

A total of 18 military pilots in their tirocinium in the air force academy from the Portuguese Air Force course "Masters in Military Aeronautics: aviator pilot specialist" participated in this study. Participants were randomly assigned to yoga (intervention group) or waiting list (control group). Procedures were approved by the Évora University research ethics committee and participants will give written informed consent according to the Helsinki declaration (approval number: 21050).

NCT ID: NCT05820659 Recruiting - Clinical trials for Stress Reaction; Acute

Racial Discrimination and Stress Response

Start date: June 29, 2023
Phase: N/A
Study type: Interventional

The goal of this study is to learn about whether ethnic minority adolescents' racial discrimination experience is related to dysregulated biological responses to subtle racism, and how the relationship may be attenuated or exacerbated by a set of social and cognitive factors. The main questions it aims to answer are: - to reveal the relationship between racial discrimination experiences and ethnic minority adolescents' stress response to subtle racism - to test parental ethnic-racial socialization, children's attribution to subtle racism and their racial identity as potential risk and protective factors.

NCT ID: NCT05799196 Recruiting - Meniscus Tear Clinical Trials

The Effectiveness of the Microfracture Technique in the Meniscal Healing

Start date: March 31, 2023
Phase:
Study type: Observational [Patient Registry]

Meniscus injuries are a very common cause of knee pain. The meniscus is a semilunar fibrocartilage structure found on the medial and lateral sides of the knee. The meniscus serves to absorb impact and protect the articular cartilage during weight-bearing activities, joint stability, proprioception, and nutrition. This has a significant effect on knee biomechanics. After the menisci are injured, the biomechanics of the knee change so that degenerative changes occur more frequently in the tibiofemoral compartment. Improvement of tibiofemoral arthrosis after meniscectomy surgery has been demonstrated in several long-term clinical studies. With increasing awareness of the importance of the meniscus in knee biomechanics, various meniscus repair techniques have been developed. In addition, several adjuvants for healing have been proposed to enhance meniscus healing. However, a study showed the meniscal repair failure rate increased from 22% to 24% at 5 years. Study found the healing rate of meniscus repair, which was accompanied by ACL repair, had a greater healing rate, 93% vs. 50%. Hemarthrosis that occurs after bony tunneling during ACL reconstruction provides a fibrin clot and an environment rich in factors that promote healing of the newly repaired meniscus. The fibrin clot provides the structural foundation for meniscus healing. Transmission factors, such as fibronectin and growth factors, are also present. Microfracture is a common procedure used for the treatment of damage to the articular cartilage in the knee. This procedure is used to stimulate the production of fibrocartilage in areas of injured cartilage. Microfractures are performed by creating 1 or more small channels (1 to 3 mm in size) that pierce the subchondral bone and release bone-forming components into the joint. Microfractures serve to promote the formation of fibrocartilage over damaged cartilage. Research in 2016 used an animal model (Capra hircus) to investigate the effectiveness of the microfracture technique on meniscus tear healing rates. They found significant healing in meniscal repair accompanied by microfracture technique (65% vs 12%). However there is still not enough research regarding the efficacy of microfracture in meniscal healing, especially among Indonesian. Therefore, the investigators aim to investigate its efficacy.

NCT ID: NCT05798052 Not yet recruiting - Clinical trials for Stress, Psychological

Effects of Stress on Team Coordination and Performance

Start date: April 2023
Phase: N/A
Study type: Interventional

Healthcare teams often encounter challenging circumstances where they must deliver high-quality care. For a team to function effectively, its members must not only be individually competent, but they also need to collaborate and cooperate using their respective expertise. Such teams often work under high stress situations, where they need to make high stakes decisions under conditions of uncertainty, time-sensitivity and variable levels of control. Research shows that such emergency situations provoke stress responses in individuals, which can impair attention, memory, reasoning, and decision-making. However, it remains unclear how individual-level stress responses influence team communication, coordination, and performance. The aims of this study are to a) compare team coordination, communication, and performance in low stress versus high stress simulated emergency situations; and b) characterize the relationship between teams' stress profiles and the teams' performance and coordination. The study will be a within-subject experimental design, with teams serving as their own controls. Teams of emergency medicine residents and nurses will participate in two simulation scenarios: one in a low stress condition, and the other in a high stress condition (counterbalanced across the teams).