The Effectiveness of the Microfracture Technique in the Meniscal Healing

Status Recruiting

Clinical Trial Summary

Meniscus injuries are a very common cause of knee pain. The meniscus is a semilunar fibrocartilage structure found on the medial and lateral sides of the knee. The meniscus serves to absorb impact and protect the articular cartilage during weight-bearing activities, joint stability, proprioception, and nutrition. This has a significant effect on knee biomechanics. After the menisci are injured, the biomechanics of the knee change so that degenerative changes occur more frequently in the tibiofemoral compartment. Improvement of tibiofemoral arthrosis after meniscectomy surgery has been demonstrated in several long-term clinical studies. With increasing awareness of the importance of the meniscus in knee biomechanics, various meniscus repair techniques have been developed. In addition, several adjuvants for healing have been proposed to enhance meniscus healing. However, a study showed the meniscal repair failure rate increased from 22% to 24% at 5 years. Study found the healing rate of meniscus repair, which was accompanied by ACL repair, had a greater healing rate, 93% vs. 50%. Hemarthrosis that occurs after bony tunneling during ACL reconstruction provides a fibrin clot and an environment rich in factors that promote healing of the newly repaired meniscus. The fibrin clot provides the structural foundation for meniscus healing. Transmission factors, such as fibronectin and growth factors, are also present. Microfracture is a common procedure used for the treatment of damage to the articular cartilage in the knee. This procedure is used to stimulate the production of fibrocartilage in areas of injured cartilage. Microfractures are performed by creating 1 or more small channels (1 to 3 mm in size) that pierce the subchondral bone and release bone-forming components into the joint. Microfractures serve to promote the formation of fibrocartilage over damaged cartilage. Research in 2016 used an animal model (Capra hircus) to investigate the effectiveness of the microfracture technique on meniscus tear healing rates. They found significant healing in meniscal repair accompanied by microfracture technique (65% vs 12%). However there is still not enough research regarding the efficacy of microfracture in meniscal healing, especially among Indonesian. Therefore, the investigators aim to investigate its efficacy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05799196
Study type	Observational [Patient Registry]
Source	Hasanuddin University
Contact	Leonard Christianto Singjie, MD
Phone	+6281212609805
Email	leonardcs@hotmail.co.id
Status	Recruiting
Phase
Start date	March 31, 2023
Completion date	December 1, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05875480` - The Effectiveness of Telerehabilitation After Arthroscopic Meniscus Repair	N/A
Terminated	`NCT01256788` - Post-op Treatment With Hyaluronic Acid Injections	N/A
Not yet recruiting	`NCT06048341` - FNB in Meniscal Tear Under SA	N/A
Not yet recruiting	`NCT06045884` - FNB in Meniscal Tear Under GA	N/A
Completed	`NCT04956393` - The SOAR (Stop OsteoARthritis) Program Proof-of-Concept Study	N/A
Completed	`NCT06227078` - Effects of Kinesiotaping and Physiotherapy in Grade 2 Osteoarthritis Following Degenerative Meniscal Tears	N/A
Recruiting	`NCT05882591` - Posteromedial Tibiofemoral Incongruence (PMTFI) Treatment	N/A
Recruiting	`NCT05322005` - Study of Clinical Performance and Safety of Treatments in Degenerative Meniscopathy With Injection of Polynucleotides	N/A
Completed	`NCT02100059` - Motor and Sensory Deficits Following Partial Meniscectomy	N/A
Completed	`NCT05370937` - Clınıcal Results of Evelator and Free Knot Methods In Medial Menıscus Posterior Root Tears	N/A
Completed	`NCT01931735` - Prospective Trial of Arthroscopic Meniscectomy for Degenerative Meniscus Tears	N/A
Completed	`NCT02237001` - Study of Suture Repair of Torn Meniscus in the Knee	N/A
Active, not recruiting	`NCT04361487` - Circumferential Compression STITCH Repairs of Complex and Horizontal Cleavage Meniscal Tears
Enrolling by invitation	`NCT04641351` - Corticosteroid Meniscectomy Randomized Trial	Phase 4
Not yet recruiting	`NCT05909865` - PRedIcting MEniscal Tears Outcomes After Physical Therapy Treatment	N/A
Enrolling by invitation	`NCT03037242` - Outcomes of Meniscus Root Repair Using a Transtibial Pullout Technique	N/A
Recruiting	`NCT05261360` - Clinical Efficacy of Exosome in Degenerative Meniscal Injury	Phase 2
Completed	`NCT05020938` - Long Term Follow-Up of KNEE PAIN Patients Accompanying Meniscus Tear
Recruiting	`NCT05335252` - Dronabinol After Arthroscopic Surgery	Phase 3
Not yet recruiting	`NCT05505747` - Enhancing Recovery Through a Combined Mechanobiologic Intervention Following Meniscus Repair	Phase 2/Phase 3

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.