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Fractures, Bone clinical trials

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NCT ID: NCT02422355 Completed - Hip Fracture Clinical Trials

A Focused Registry on the Femoral Neck System (FNS) in Patients With Femoral Neck Fractures

FR_FNS
Start date: September 30, 2017
Phase:
Study type: Observational [Patient Registry]

In comparison to previous implants, the Femoral neck system (FNS) is an approved implant by the competent authorities (CE mark). It is designated to stabilize medial femoral neck fractures in a minimal invasive technique. The implant combines an angular stable device with screw in screw technology for rotational stability. Therefore the purpose of this focused registry is to investigate how the newly developed and approved implant called FNS is performing clinically and radiologically in terms of surgical technique, intra- and postoperative complications and short term outcome.

NCT ID: NCT02410070 Completed - Clinical trials for Closed Frykman Type II Fracture of Right Radial Head

A Comparison of Minimal Approach With Conventional Approach for Distal Radial Fractures

Start date: January 2011
Phase: N/A
Study type: Interventional

The objective of this study is to compare a minimal invasive approach with the conventional flexor carpi radialis approach for volar plating of distal radial fractures.

NCT ID: NCT02409082 Completed - Inflammation Clinical Trials

Alzheimers Disease and Neuromarkers in Patients With Acute Hip Fractures

ADhipfract
Start date: September 11, 2013
Phase: N/A
Study type: Observational

The investigators explore the presence of AD factors beta-amyloid and tau in CSF and plasma to verify AD diagnosis in patients with acute hip fracture. Clinical dementia test is performed prior to operation. Blood samples and CSF samples are collected at surgery and blood samples are collected postoperatively at intervals. Mortality is assessed at 30 days, 3 months and 1 year. Morbidity is assessed at , 3 months and >1 year. Neuromarkers specifically addressing the inflammatory component are to be analyzed and correlated to outcome together with AD markers, as above.

NCT ID: NCT02402868 Completed - Bone Fractures Clinical Trials

Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children

Start date: January 2016
Phase: Phase 3
Study type: Interventional

This study will examine the effectiveness of intranasal (IN) ketamine compared to standard intravenous (IV) ketamine administration for simple reductions of orthopaedic injuries in the paediatric population. The aim is to assess if IN administration is equivalent to the current standard of care, IV. The population to be studied is children 5-17 years of age who require a simple orthopaedic reduction. Following a double dummy approach to overcome the difficulty in masking interventions, each participant will recieve both IV and IN interventions, only one of which will be the real drug. Procedural conscious sedation (PCS) will be assessed using the University of Michigan Sedation Scale (UMSS).

NCT ID: NCT02391129 Completed - Clinical trials for Periprosthetic Fractures

Locking Compression Plate Fixation Versus Revision- Prosthesis of Vancouver-B2, B3 and C Periprosthetic Femoral Fractures After Total Hip Replacement

Start date: January 2014
Phase: N/A
Study type: Observational

The purpose of this study was to compare the clinical (range of motion, weight bearing, quality of life) and radiographic outcome (boney consolidation) between open reduction and internal fixation using locking compression plates with revision prosthesis using a non-cemented long femoral stem in a group of patients with a Vancouver type-B2, B3 and C periprosthetic fracture after primary total hip replacement.

NCT ID: NCT02382185 Completed - Hip Fractures Clinical Trials

Non Invasive Cardiac Output Monitoring to Guide Goal Directed Fluid Therapy in High Risk Patients Undergoing Urgent Surgical Repair of Proximal Femoral Fractures

ClearNOF
Start date: January 2015
Phase: N/A
Study type: Interventional

Improving or maximising cardiac output in the perioperative setting through the use of goal directed fluid therapy has been shown to reduce complications and length of hospital stay in patients undergoing major abdominal surgery. The evidence for patients having surgery to repair a fractured neck of femur is less robust but many of these latter patients are elderly and often at high risk of complications. Patients undergoing surgery (including surgery for hip fracture) under spinal anaesthesia have not had access to goal directed fluid therapy because of the invasive nature of the existing monitoring technology such as oesophageal doppler. The availability of a non invasive cardiac monitoring device, the Clearsightâ„¢, now makes goal directed fluid therapy a possibility for this group of patients. This is a randomised controlled, observer blinded trial to assess the effects of goal directed fluid therapy in high-risk patients undergoing surgical repair of proximal femoral fractures. The aim of the trial is to test the hypothesis that maximising circulating volume intra-operatively with balanced crystalloid reduces post-operative morbidity in high-risk patients undergoing urgent surgical repair of proximal femoral fractures.

NCT ID: NCT02373904 Completed - Clinical trials for Humerus Pathological Fracture

A Safety and Efficacy Study of the Treatment of Impending and Actual Pathological Fractures in the Humerus From Metastatic Bone Disease

Start date: February 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to collect safety and performance data of the Photodynamic Bone Stabilization System (PBSS) when used for the treatment of painful impending and actual fractures of the humerus secondary to metastatic cancer.

NCT ID: NCT02373254 Completed - Ankle Fracture Clinical Trials

NSAIDS Versus Opioids in Acute SER II Ankle Fractures

Start date: January 2015
Phase: Early Phase 1
Study type: Interventional

This study is being conducted to evaluate whether NSAIDS are more or less effective in bone healing than opioids in acute fracture pain. Participants will be randomized to one of three groups for first line treatment of pain related to the fracture.

NCT ID: NCT02353338 Completed - Radius Fracture Clinical Trials

Distal Radial Fractures in the Late Middle Aged

RIST
Start date: May 22, 2015
Phase: N/A
Study type: Interventional

Background: Wrist fractures are a common injury among people aged 55-70. The radius is one of the bones making up the wrist joint, and is typically the site of injury in a broken wrist. Methods of treating a broken radius include placing the wrist in a cast for 6 weeks (conservative management) or receiving surgery. Surgery allows for earlier movement of the wrist and return to activity, while being placed in a cast is less invasive than surgery. Surgery to fix these fractures has become more common; however there is little agreement about who should receive surgery and who should be placed in a cast to heal. The goal of this study is to compare outcomes between people aged 55-70 who have broken their wrist and had surgery, and those who received a cast. Procedures: Participants in this study will be randomly assigned to one of two study groups within 1 week of injury at their first clinic visit with the surgeon. Patients in Group A (surgical management) will continue with casting for a total of 6 weeks, as indicated by the surgeon. Patients in Group B (conservative management) will receive surgery, and the attending surgeon will determine the best fracture fixation method for the wrist. The research coordinator will assess the injured wrist at 6 weeks, 3, 6, and 12 months after the initial injury. At each assessment, the wrist will be examined and participants will be asked to fill in some questionnaires about health, pain, wrist function, and satisfaction with the wrist. An X-ray will also be performed on the wrist to assess bone healing. Information from each visit will be used to determine how participants are doing and to compare the 2 study groups.

NCT ID: NCT02348437 Completed - Radius Fractures Clinical Trials

Repair vs Non-repair of the Pronator Quadratus Muscle in Distal Radius Fractures. RCT.

Start date: February 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the functional outcome of repairing the pronator quadratus (PQ) muscle in subjects operated for a distal radius fracture (DRF) with volar locked plating.