Fatigue Clinical Trial
Official title:
Assessment of Ventilatory Efficacy in Patients With Fatigue Associated With SARS-CoV2 Infection After Ingestion of Beet Juice
The lung is the organ most affected by COVID-19. There are patients who successfully overcome the acute COVID-19 infection and their lungs return to a normal state. However, a significant number present dyspnea and fatigue as sequelae without having a pulmonary origin, but with a significant impact on functionality. In our published studies in relation to fatigue in patients with symptoms attributed to persistent COVID, the investigators have shown that there is muscle involvement, observing a decrease in mechanical efficiency. This muscle involvement causes stimulation of ventilation through the ergoreceptors, causing ineffective ventilation. This affectation can be explained by the findings obtained in the muscle biopsies that the investigators have performed, where the investigators observed a splitting of the basement membrane of the capillaries causing an alteration in the diffusion of metabolic substrates and oxygen. The main objective of our project is to be able to observe the response in ventilatory efficiency in patients with symptoms of post-covid fatigue after ingesting beet juice.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | May 31, 2024 |
Est. primary completion date | January 31, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility | Inclusion Criteria: - Patients with fatigue after SARS CoV2 infection. - Written informed consent signed by the study candidates (see Addendum 1), after receiving complete information about the objectives, techniques and possible consequences of the study. Exclusion Criteria: - Previous cardiovascular, oncological, neuromuscular or metabolic pathologies that could interfere with the results. - Significant alcoholism (>80 g/day) or severe malnutrition - Chronic treatment with drugs with potential effects on muscle structure and function - Patient treated with nitrates - Patients diagnosed prior to the infection with fibromyalgia or chronic fatigue. - Patient who has a contraindication to carrying out a stress test. - Patients allergic to beets |
Country | Name | City | State |
---|---|---|---|
Spain | Eulogio Pleguezuelos | Mataró | Barcelona |
Lead Sponsor | Collaborator |
---|---|
Hospital de Mataró |
Spain,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | VO2max | maximum oxygen consumption | 1 determination per week for 3 weeks | |
Primary | CMT | Maximum Tolerated Load | 1 determination per week for 3 weeks |
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