Fatigue Clinical Trial
Official title:
Eszopiclone for Improving Sleep Continuity in MS Patients With Sleep Disturbances and Its Impact on Daytime Fatigue
The purpose of this study is to determine if people with multiple sclerosis (MS) and fatigue
have disrupted sleep, as was suggested in previous studies, and whether treating the
disruptions of sleep improves the fatigue.
Eszoplicone, a new drug FDA approved for the treatment of insomnia, will be used to control
sleep disturbances in MS patients with fatigue.
The study will last 7 weeks, 5 of which will involve being on medication. You will take
eszopiclone or placebo (sugar pill), keep a sleep diary and wear an actigraph, a device
about the size of a digital watch that monitors and records sleep activity. You will
randomly be chosen to get either placebo or medication. Half the subjects will get placebo
and half eszopiclone. The decision will be made by a pharmacist (who does not know you)
according to a randomization table. Neither you nor the investigating physician will know
whether you are on sugar pill or medication. At both the beginning and the conclusion of the
study you will be asked to fill out 2 questionnaires to evaluate fatigue and depression and
undergo some memory and speech tests. The testing will take about 2 hours. Actigraphy is a
wrist-worn, watch like device that records activity during waking and sleeping without
application of any sensors. It consists of a movement detector, so it can record movement
and non-movement data for a week or two. You should wear it continuously during wakefulness
and sleep as you go about routine daily activities. You should only take it off if you are
going to shower, bathe or swim. A sleep log is a graph on which, for 2 to 3 weeks, you will
record bedtime, approximate sleep time, times and duration of awakenings during the sleep
period, final awakening time, and naps taken during the day to the best of your knowledge.
You will also be asked to avoid getting pregnant. If you are a woman who may have the
potential to get pregnant then a pregnancy test may be performed at the beginning of the
study, before you receive the medication, at the first follow up visit and when you end the
study.
The purpose of this study is to determine if people with multiple sclerosis (MS) and fatigue
have disrupted sleep, as was suggested in previous studies, and whether treating the
disruptions of sleep improves the fatigue.
Eszoplicone, a new drug FDA approved for the treatment of insomnia, will be used to control
sleep disturbances in MS patients with fatigue.
The study will last 7 weeks, 5 of which will involve being on medication. You will take
eszopiclone or placebo (sugar pill), keep a sleep diary and wear an actigraph, a device
about the size of a digital watch that monitors and records sleep activity. You will
randomly be chosen to get either placebo or medication. Half the subjects will get placebo
and half eszopiclone. The decision will be made by a pharmacist (who does not know you)
according to a randomization table. Neither you nor the investigating physician will know
whether you are on sugar pill or medication. At both the beginning and the conclusion of the
study you will be asked to fill out 2 questionnaires to evaluate fatigue and depression and
undergo some memory and speech tests. The testing will take about 2 hours. Actigraphy is a
wrist-worn, watch like device that records activity during waking and sleeping without
application of any sensors. It consists of a movement detector, so it can record movement
and non-movement data for a week or two. You should wear it continuously during wakefulness
and sleep as you go about routine daily activities. You should only take it off if you are
going to shower, bathe or swim. A sleep log is a graph on which, for 2 to 3 weeks, you will
record bedtime, approximate sleep time, times and duration of awakenings during the sleep
period, final awakening time, and naps taken during the day to the best of your knowledge.
You will also be asked to avoid getting pregnant. If you are a woman who may have the
potential to get pregnant then a pregnancy test may be performed at the beginning of the
study, before you receive the medication, at the first follow up visit and when you end the
study.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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