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Esophageal Cancer clinical trials

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NCT ID: NCT03468634 Completed - Esophageal Cancer Clinical Trials

Raman Probe for In-vivo Diagnostics (During Oesophageal) Endoscopy

RaPIDE
Start date: September 21, 2023
Phase: N/A
Study type: Interventional

To develop and endoscopic Raman spectroscopy probe for delivery down and channel in an endoscope to make near instant assessments of the condition of the oesophagus without the need for expensive and distressing tissue removal (biopsies).

NCT ID: NCT03462524 Completed - Surgery Clinical Trials

Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology

Start date: January 1, 2010
Phase: N/A
Study type: Observational

Although recent global trends indicate reduced postoperative mortality after esophagectomy, major morbidity, in particular pulmonary, remains high, with considerable health and economic costs. In a recent modern international collaborative series of 2704 patients from high-volume centers, with an approximate equal mix of open and minimally invasive approaches, respiratory complications were evident in 28% of patients, pneumonia in 15%, and respiratory failure in 7%.1 In other series, respiratory failure is reported in up to 15% of patients and is the most common cause of mortality. Prediction of risk and prevention of respiratory morbidity is therefore of considerable importance, and in this context baseline assessment of respiratory physiology compliments clinical assessment, history and enhanced recovery pathways representing key elements of current patient management. In this study, which will include all prospective patients with locally advanced esophageal cancer treated at a National Center, pulmonary function will be systematically measured before and after neoadjuvant therapy. The investigators seek to evaluate the incidence of radiation induced lung injury (RILI), as well as subclinical changes in pulmonary physiology that may be linked to postoperative complications, and quality-of-life in survivorship, and to compare cohorts who received radiation therapy or chemotherapy alone, preoperatively.

NCT ID: NCT03461341 Completed - Surgery Clinical Trials

European iNvestigation of SUrveillance After Resection for Esophageal Cancer

ENSURE
Start date: June 1, 2009
Phase:
Study type: Observational

The ENSURE study will comprise two phases. Phase 1: European multicenter survey of surveillance protocols after esophageal cancer surgery ENSURE questionnaire will be circulated to representatives from participating European countries. Phase 2: European multicenter retrospective observational study of the impact of postoperative surveillance protocols on oncologic outcome and HR-QL Phase 2 will constitute a retrospective observational study of patients undergoing treatment with curative intent for esophageal cancer at participating Centers from June 2009 to June 2015.

NCT ID: NCT03457506 Completed - Breast Cancer Clinical Trials

Intra-individual Comparison of Conventional and Digital PET/CT Scanners

Start date: January 8, 2018
Phase: N/A
Study type: Interventional

In this study, the investigators will analyze the impact of digital PET/CT on the final diagnostic conclusion of the scan in patients with lung cancer, breast cancer, esophageal cancer and a group of mescellaneous cancers.

NCT ID: NCT03428074 Completed - Esophageal Cancer Clinical Trials

A Observational Study to Compare Effectiveness and Safety of the Surgeries in Patients With Esophageal Cancer

Start date: December 1, 2017
Phase:
Study type: Observational

The study was designed to compare effectiveness and safety of the surgeries of Ivor-Lewis and Mckeown in patients with esophageal cancer

NCT ID: NCT03418298 Completed - Gastric Cancer Clinical Trials

Prehabilitation in Patients With Esophageal or Gastric Cancers

Start date: February 27, 2018
Phase: N/A
Study type: Interventional

Objectives: The primary objective of this study is to assess the feasibility of a internet-based preoperative exercise program in patients with esophageal or gastric cancers. Secondary objectives are to evaluate the effects of this preoperative program on functional capacity, anxiety and depression, quality of life and fatigue Methods: This feasibility study will be conduct at University Hospital Saint-Luc in Brussels. Twenty patients with esophageal or gastric cancers will participate in internet-based program 3 sessions per week. Each session will combine aerobic and resistance training. Moreover, inspiratory muscle strengthening (IMT) will be performed daily. The researcher will conduct weekly telephone calls to educate and motivate subjects. Assessments will be performed at baseline, one day before surgery, 1 month and 3 months after surgery. The following parameters will be measured: functional capacity, quality of life, fatigue, anxiety and depression.

NCT ID: NCT03416244 Completed - Esophageal Cancer Clinical Trials

A Multicenter Open-label Phase II Trial to Evaluate Nivolumab and Ipilimumab for 2nd Line Therapy in Elderly Patients With Advanced Esophageal Squamous Cell Cancer

RAMONA
Start date: February 21, 2018
Phase: Phase 2
Study type: Interventional

Cancer - including esophageal squamous cell cancer (ESCC) - is a disease of the elderly but little is known about the biology and progression of cancers in these patients. While most patients receive chemotherapy and/or chemo-radiation as first treatment, no treatment standard for following treatments has been established so far and there is a clear unmet medical need, especially for elderly patients. Hence, this study assesses the efficacy and safety of two experimental immunotherapy regimens (Nivolumab monotherapy or Nivolumab/Ipilimumab combination) in elderly patients with advanced esophageal squamous cell cancer.

NCT ID: NCT03413436 Completed - Esophageal Cancer Clinical Trials

Lobaplation or Cisplatin in Adjuvant Chemotherapy for Esophageal Carcinoma

Start date: January 31, 2018
Phase: Phase 4
Study type: Interventional

The multicenter real-world and propensity score matching comparative study was designed to explore the toxicity and effectiveness of Lobaplation or Cisplatin based adjuvant chemotherapy in esophageal carcinoma

NCT ID: NCT03410758 Completed - Esophageal Cancer Clinical Trials

Predictive Factors of Survival With and Without Repetition With 5 and 10 Years Curative Post-oesophagectomy for Cancer of the Oesophagus

RESARPO
Start date: February 15, 2016
Phase: N/A
Study type: Observational

Prospective study of Predictive Factors of Survival With and Without Repetition With 5 and 10 Years Curative Post-oesophagectomy for Cancer of the Oesophagus

NCT ID: NCT03409848 Completed - Gastric Cancer Clinical Trials

Ipilimumab or FOLFOX in Combination With Nivolumab and Trastuzumab in HER2 Positive EsophagoGastric Adenocarcinoma

INTEGA
Start date: March 1, 2018
Phase: Phase 2
Study type: Interventional

The INTEGA study assesses therapy Options for advanced or metastatic esophagogastric Adenocarcinoma in patients overexpressing human epidermal receptor type 2 (HER2 positive patients). Current treatment options in this situation include chemotherapy based palliative treatment in combination withTrastuzumab. Recent studies have shown that immunotherapy with Nivolumab or Ipilimumab after previous chemotherapy can also improve survival in esophagogastric cancer. This study assesses the efficacy of two experimental first line treatment strategies: A) Chemo-free immunotherapy with Trastuzumab, Nivolumab and Ipilimumab and B) addition of Nivolumab to the standard regimen (FOLFOX chemotherapy and Trastuzumab).