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Esophageal Cancer clinical trials

View clinical trials related to Esophageal Cancer.

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NCT ID: NCT05523960 Completed - Esophageal Cancer Clinical Trials

Mechanical Bowel Preparation Versus no Bowel Preparation for Esophageal Cancer Surgery

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

The study type was designed as a prospective multicenter randomized controlled study. The patients will be divided into intervention group and control group, 281 patients were needed for each group and 562 patients would be needed totally to show this difference. Due to a possible loss of 14%, the final sample size was calculated to be 652 patients. The intervention group will not implement mechanical bowel preparation(MBP) before surgery; the control group will receive routine preoperative MBP for oral administration of compound polyethylene glycol electrolyte powder and fasting water. Perioperative complications, intestinal recovery speed and quality of life will be investigated between the two groups.

NCT ID: NCT05499195 Completed - Esophageal Cancer Clinical Trials

Adjuvant Radiotherapy for pT1b Esophageal Cancer After Submucosal Endoscopic Resection

Start date: March 1, 2021
Phase:
Study type: Observational

Endoscopic Resection (ER) is a crucial therapeutic and diagnostic method for superficial esophageal cancer. However, lymph node metastasis rate in pT1b patients is relatively high. Although, adjuavnt chemoradiotherapy is recommended, limied studies prove the superiority of additional adjuvant radiotherapy over ESD alone. This study aimed to further verify the efficacy of adjuvant radiotherapy in early-stage esophageal cancer after ESD.

NCT ID: NCT05431621 Completed - Colorectal Cancer Clinical Trials

Establishment of Molecular Classification Models for Early Diagnosis of Digestive System Cancers

Start date: November 15, 2020
Phase:
Study type: Observational

This is a single blind, case control, multicenter study jointly developed by Zhongshan Hospital of Fudan University, Shanghai Public Health Clinical Center, Shanghai Xuhui Central Hospital, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, and Shanghai Singlera Genomics Company. The enrolled population will include positive group, precancerous lesions and healthy control group, which is expected to enroll 2,430 participants. The primary objective is to establish molecular testing methods for non-invasive screening and early diagnosis of digestive system cancers through ctDNA methylation and mutation, cfDNA and ctDNA fragment size, and end motif based model (for esophageal, gastric, colorectal cancer), and through ctDNA methylation detection, ctDNA low-pass WGS, miRNA7 and CTC detection and analysis technology based model (for hepatocellular carcinoma). The sensitivity and specificity of the models in cancer early detection will be evaluated.

NCT ID: NCT05318404 Completed - Surgery Clinical Trials

Conventional Oral Intake vs Delayed Oral Intake With Jejunostomy Feeding After Esophagectomy (JNS Study)

JNS
Start date: December 8, 2020
Phase: N/A
Study type: Interventional

Comparison of nutritional and early surgical outcome between early and delayed oral feeding after esophagectomy for esophageal cancer

NCT ID: NCT05082948 Completed - Esophageal Cancer Clinical Trials

Migration Rates of Sutured vs Non-sutured Esophageal Stent Placement

Start date: July 20, 2021
Phase: N/A
Study type: Interventional

No standard approach currently exists for endoscopic esophageal stent placement, and both sutured and un-sutured techniques are employed for esophageal stent placement currently. The primary purpose of this study is to find out if suture fixation of esophageal stents is superior to non-suture fixated stent placement. Consecutive patients who are scheduled for esophageal stent placement will be identified as potential study participants by study personnel and will be approached on the day of the procedure. Informed consent will be obtained and patients will be randomized into suture fixation and non-suture fixation groups. Patients in the suture fixation group will have their esophageal stent secured in location with two endoscopic sutures. Those in the non-suture fixation group will have no sutures placed. Main study outcome is stent migration, and rates of stent migration will be compared in the two groups.

NCT ID: NCT05030870 Completed - Gastric Cancer Clinical Trials

Capnographic Monitoring in Gastrointestinal Endoscopy for Elderly Patients

CapnoGI
Start date: September 1, 2021
Phase: N/A
Study type: Interventional

Hypoxia is the most common adverse event in gastrointestinal endoscopes sedated with propofol and sufentanil, especially in elderly people. The aim of this randomized study was to determine whether intervention based on additional capnographic monitoring reduces the incidence of hypoxia in gastrointestinal endoscopes procedures for elderly patients.

NCT ID: NCT04958044 Completed - Esophageal Cancer Clinical Trials

Endoscopic Assisted Calcium Electroporation in Esophageal Cancer

Start date: May 25, 2021
Phase: Phase 1
Study type: Interventional

In this pilot study, patients with non-curable esophageal cancer will be treated with endoscopic assisted calcium electroporation (CaEP). CaEP is a novel cancer treatment where intratumoral injection with calcium is combined with locally applied electrical pulses, in order to increase calcium influx which leads to tumor necrosis. It is hypothesized that: - Endoscopic assisted CaEP is a safe and feasible procedure in patients with non-curable esophageal cancer - CaEP debulks the tumor, facilitating the patient's ability to eat and drink In this single-arm pilot study, eight patients will be treated.

NCT ID: NCT04896242 Completed - Breast Cancer Clinical Trials

Multimodal Assesment of Acute Cardiac Toxicity Induced by Thoracic Radiotherapy in Cancer Patients

Start date: January 9, 2020
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to evaluate and compare the changes by two modalities: Imaging by Strain by Speckle Tracking and Magnetic Resonance versus soluble markers of cardiac dysfunction as early predictors of cardio-toxicity in cancer patients receiving low or high doses of radiotherapy.

NCT ID: NCT04837677 Completed - Breast Cancer Clinical Trials

A Study of PRT1419 in Patients With Advanced Solid Tumors

Start date: August 11, 2021
Phase: Phase 1
Study type: Interventional

This is a Phase 1 dose-escalation study of PRT1419, a myeloid cell leukemia 1 (MCL1) inhibitor, in patients with advanced solid tumors. The purpose of this study is to define the dosing schedule, maximally tolerated dose and/or estimate the optimal biological dose to be used in subsequent development of PRT1419.

NCT ID: NCT04822103 Completed - Esophageal Cancer Clinical Trials

A Real-World Study of Immune Checkpoint Inhibitors and Chemotherapy for Advanced Esophageal Cancer

Start date: January 1, 2021
Phase:
Study type: Observational

The role of preoperative chemotherapy as standard therapy is well-established for advanced esophageal cancer. Immunotherapeutic agents such as Immune checkpoint inhibitors has been shown to improve objective response rate in solid tumors. However, there is a paucity of data regarding the efficacy and safety of preoperative immunotherapy plus chemotherapy in esophageal cancer patients in real-world practice. This study set out to investigate whether the combination of preoperative chemotherapy and immune checkpoint inhibitors is beneficial to improve the objective response rate as well as the pathological complete response rate in a real-world scenario.