Healthy Clinical Trial
Official title:
Effect of Probiotics on Systemic Inflammation and Insulin Resistance in Type 2 Diabetics and Healthy Controls
Insulin-resistance in type 2 diabetes is associated with chronic inflammation.
Anti-inflammatory actions might increase sensitivity to insulin. Since some probiotics have
anti-inflammatory properties, ingestion of the probiotic bacteria Lactobacillus Acidophilus
NCFM might increase insulin-sensitivity.
The inflammatory response to endotoxin injection and the insulin-sensitivity is examined
before and after four weeks ingestion of probiotics.
Numerous studies have shown an association between insulin-resistance in type 2 diabetes and
chronic low-grade inflammation. Some probiotics have an anti-inflammatory properties.
Ingestion of probiotics might therefore, due to this property, increase sensitivity to
insulin.
In this study type 2 diabetics (N=24) and healthy control (N=24) are given the probiotic
bacteria Lactobacillus Acidophilus NCFM for four weeks. The anti-inflammatory effect is
examined by evaluating the inflammatory response (White blood cell count, plasma-cytokines)
to an iv injection of endotoxin (0,3 ng/kg) before and after the intervention. Also the
insulin-sensitivity is measured with an hyperinsulinemic euglycemic clamp before and after
L. acidophilus NCFM.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Prevention
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