Coronary Arteriosclerosis Clinical Trial
Official title:
Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease
The purpose of this study is to determine the effect of orally given paracetamol on the vascular function and on 24-hour blood pressure in patients with coronary artery disease
Patients with chronic pain diseases (e.g. osteoarthritis) are dependent on effective
medication. NSAIDs are very effective in lowering pain in these patients. Recently there has
aroused major concern with regard to cardiovascular side effects and safety, especially in
selective cyclooxygenase-2 inhibitors (coxibs) but also in "regular" NSAIDs.
At the moment, there is a big confusion, whether these drugs still should be used, especially
in patients with known coronary artery disease. Physicians now try to switch to high dose
paracetamol, despite the weaker efficacy in pain relieve, because this drug is considered
generally as not harmful.
As there is very few information on the cardiovascular effect of this drug, we plan to
perform this study and investigate the impact of paracetamol on endothelial function, an
important cardiovascular surrogate marker, on inflammatory markers and on oxidative stress in
patients with coronary artery disease on top of standard medication, including aspirin
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00069654 -
Dietary Nitrate and Nitrite to Increase Nitric Oxide in Patients With Coronary Artery Disease
|
Phase 2 | |
| Completed |
NCT02919124 -
Epicardial Echocardiography of Coronary Anastomoses Using the Echoclip Device
|
N/A | |
| Recruiting |
NCT02639962 -
Characteristics of Culprit Lesion and Changes in Plaque Composition. A Dual Energy Cardiac CT Study
|
N/A | |
| Completed |
NCT02494557 -
Risk Stratification for Coronary Artery Disease With Type 2 Diabetic Patients
|
N/A | |
| Recruiting |
NCT01466452 -
Antiplatelet Effect of Low Doses of Aspirin Taken Every 12 Hours in Patients Undergoing Coronary Artery Bypass Graft and/or Aortic Valve Surgery
|
Phase 2 | |
| Completed |
NCT01182428 -
XIENCE V: SPIRIT WOMEN Sub-study
|
Phase 4 | |
| Completed |
NCT00371891 -
Ontario Multidetector Computed Tomographic (MDCT) Coronary Angiography Study (OMCAS)
|
Phase 4 | |
| Completed |
NCT00368953 -
YUKON Choice Versus TAXUS Liberté in Diabetes Mellitus
|
Phase 4 | |
| Completed |
NCT00319449 -
Adding Ezetimibe Tablet to Ongoing Treatment With Atorvastatin in Subjects With High Cholesterol and Multiple Coronary Heart Disease Risk Factors (Study P04060)(COMPLETED)
|
Phase 4 | |
| Completed |
NCT00091754 -
Atherosclerosis, Plaque and CVD in Communities
|
||
| Completed |
NCT00069797 -
Epidemiology of Coronary Heart Disease in Men Aged 40 and Over
|
N/A | |
| Completed |
NCT00037245 -
Androgens and Subclinical Atherosclerosis in Young Women - Ancillary to CARDIA
|
N/A | |
| Completed |
NCT00024596 -
Family Heart Study - Subclinical Atherosclerosis Network (FHS-SCAN)
|
N/A | |
| Completed |
NCT00006407 -
Sex Steroid Hormones and Risk of CHD in Women
|
N/A | |
| Completed |
NCT00006502 -
Myocardial Perfusion, Risk Factors, and Coronary Calcium
|
N/A | |
| Withdrawn |
NCT00006497 -
Long-Term Effects of Subclinical CAD on Cardiac Function
|
||
| Completed |
NCT00006309 -
Pooling of Cohort Studies on Diet & Coronary Disease
|
N/A | |
| Completed |
NCT00005269 -
Family Blood Pressure Program - GENOA
|
||
| Completed |
NCT00000508 -
Stanford Coronary Risk Intervention Project (SCRIP)
|
Phase 3 | |
| Completed |
NCT00005147 -
Epidemiology of Atherosclerosis
|
N/A |