End-stage Heart Failure Clinical Trial
Official title:
Perioperative Modification of Hemostasis During Ventricular Assist Device Implantation
Implanting a ventricular assist device (VAD) is a promising therapy for end-stage cardiac
failure. However, the implantation of these devices is associated with a high risk of severe
hemorrhages and massive blood product transfusion in the first 48 hours following the
implantation. The primary purpose of this study is to assess the functionality of the von
Willebrand Factor (vWF) which is essential for hemostasis. The hypothesis is that the high
shear stress generated by these VAD expose ADAMTS13 cleaving site on the vWF. This result in
a loss of high molecular weight vWF and an acquired von Willebrand syndrome.
The secondary purpose of the protocol is to assess platelet function after the implantation
of VAD. Indeed, platelet function might be affected shortly after the implantation of the
device.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT06063811 -
Ventricular Tachycardia Ablation in LVAD Patients
|
||
| Withdrawn |
NCT04782245 -
Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting List
|
Phase 2 | |
| Active, not recruiting |
NCT04351945 -
Endocrine Changes and Their Correction in Heart and Lung Transplant Recipients and Donors
|
||
| Recruiting |
NCT02592499 -
Swedish Evaluation of Left Ventricular Assist Device as Permanent Treatment in End-stage Heart Failure
|
N/A | |
| Active, not recruiting |
NCT00490321 -
VentrAssistTM LVAD for the Treatment of Advanced Heart Failure - Destination Therapy
|
Phase 3 | |
| Active, not recruiting |
NCT00483197 -
VentrAssistTM LVAD as a Bridge to Cardiac Transplantation - Pivotal Trial
|
Phase 3 | |
| Completed |
NCT04543747 -
Mechanical Circulatory Support Korea Post Market Surveillance Study (PMS)
|
||
| Recruiting |
NCT04293575 -
Transcatheter Mitral Valve Repair as Bridge Therapy to Heart Transplantation
|
||
| Recruiting |
NCT04641416 -
Noninvasive Cardiovascular Diagnosis of Patients With Fully Magnetically Levitated Blood Pumps
|
||
| Completed |
NCT00490347 -
VentrAssistTM LVAD as a Bridge to Cardiac Transplantation - Feasibility Trial
|
Phase 2 | |
| Suspended |
NCT04117295 -
Carmat TAH Early Feasibility Study
|
N/A | |
| Completed |
NCT05353816 -
Corheart 6 Left Ventricular Assist System Prospective, Multicenter, Single-arm Clinical Evaluation Trial
|
N/A | |
| Completed |
NCT04480151 -
ECLS Versus IMPELLA™ as Bridge to LVAD (ECI-BLAD)
|
||
| Recruiting |
NCT04205760 -
Preoperative Nutritional Optimization and Physical Exercise for Patients Scheduled for Elective Implantation for a Left-Ventricular Assist Device
|
Phase 3 | |
| Recruiting |
NCT06345521 -
Etablishment of Follow-up System and End-Stage Heart Registration Platform for Pediatric Heart Failure
|
||
| Recruiting |
NCT04768322 -
LVAD Versus GDMT in Ambulatory Advanced Heart Failure Patients
|
N/A | |
| Completed |
NCT02248974 -
Development & Testing of a Decision Aid for LVAD Placement
|
N/A | |
| Completed |
NCT06152562 -
Evaluation of Platelet Therapy Response in Left Ventricular Assist Device Patients
|
||
| Completed |
NCT05928273 -
Corheart 6 LVAS LTFU
|
N/A | |
| Recruiting |
NCT04951999 -
AssocIation of PULSatility and Occurrence of Complications Related to Mechanically Assisted Circulatory Support
|
N/A |