End-stage Heart Failure Clinical Trial
Official title:
Perioperative Modification of Hemostasis During Ventricular Assist Device Implantation
Implanting a ventricular assist device (VAD) is a promising therapy for end-stage cardiac
failure. However, the implantation of these devices is associated with a high risk of severe
hemorrhages and massive blood product transfusion in the first 48 hours following the
implantation. The primary purpose of this study is to assess the functionality of the von
Willebrand Factor (vWF) which is essential for hemostasis. The hypothesis is that the high
shear stress generated by these VAD expose ADAMTS13 cleaving site on the vWF. This result in
a loss of high molecular weight vWF and an acquired von Willebrand syndrome.
The secondary purpose of the protocol is to assess platelet function after the implantation
of VAD. Indeed, platelet function might be affected shortly after the implantation of the
device.
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