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End-stage Heart Failure clinical trials

View clinical trials related to End-stage Heart Failure.

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NCT ID: NCT03356353 Not yet recruiting - Clinical trials for End Stage Heart Failure

Sildenafil for the Prevention of Right Heart Failure Following LVAD Implantation

Start date: December 2017
Phase: Phase 3
Study type: Interventional

Continuous-flow left ventricular assist devices (LVAD) move blood from the left ventricle (the largest chamber of the heart) to the aorta (the body's main artery) to help the heart better meet the needs of the body and to improve survival for patients with advanced heart failure (HF). The ability of the right ventricle (the large chamber on the right side of the heart) to keep up with the improved blood flow following LVAD greatly effects how well a person does following surgery. It is understood that a high pulmonary artery pressure (pressure in the blood vessel that takes blood from the right side of the heart to the lungs) measured before surgery, indicates that a higher risk of right heart failure exists after LVAD implantation. This is important because right heart failure after surgery is related to longer intensive care unit (ICU) and hospital stays, increased morbidity (other health problems) including organ failure and worse outcomes following heart transplant, and increased death rates. Sildenafil (Revatio®) has been approved by Health Canada in the treatment of pulmonary arterial hypertension (high blood pressure in the lungs) in patients with connective tissue disease. Sildenafil has not yet been approved by Health Canada for the treatment of pulmonary hypertension in heart failure. Sildenafil lowers blood pressure in the lungs and lessens the workload of the right ventricle (the right side of the heart). The purpose of this study is to determine if lowering blood pressure in the lungs, in heart failure patients at risk for developing right heart failure after LVAD implant, lowers the incidence of right heart failure, shortens ICU and hospital stays and reduces morbidity (other health problems) and mortality (death rates). This is an open label, single arm study. Everyone who participates in this study will receive sildenafil before and after LVAD surgery. It is expected that 24 patients who are scheduled to have LVAD implantation for advanced heart failure will be enrolled from 6 sites across Canada. Participants will be followed in the study for about 2 months.

NCT ID: NCT02592499 Recruiting - Clinical trials for End-stage Heart Failure

Swedish Evaluation of Left Ventricular Assist Device as Permanent Treatment in End-stage Heart Failure

SweVAD
Start date: June 2016
Phase: N/A
Study type: Interventional

The study is a prospective, randomized, non-blinded, national, multi-center study. The study will consist of the assignment of eligible patients to treatment with either a HeartMate III (HM III) left ventricular assist device system or to pharmacological treatment (optimal medical management, OMM) according to current guidelines. One hundred and forty (140) patients will be enrolled in this study and randomized in a 1:1 fashion between the HM III and OMM.

NCT ID: NCT02248974 Completed - Clinical trials for End-Stage Heart Failure

Development & Testing of a Decision Aid for LVAD Placement

VADDA
Start date: February 2014
Phase: N/A
Study type: Interventional

The goal of this project is to develop a patient-centered decision aid for decision-making about end-stage heart failure treatment. This study seeks to create a decision aid that presents outcomes, risks, projected experiences, and uncertainties about Left Ventricular Assist Device (LVAD) placement to help patients make values-based decisions about placement. The investigators propose a mixed methods design involving a literature search of clinical evidence, semi-structured patient interviews, and quantitative data from a multi-site trial of patients receiving the decision aid compared to patients not receiving the aid.

NCT ID: NCT02174133 Completed - Clinical trials for End Stage Heart Failure

Impact of LVAD Implantation on Micro- and Macrovascular Function

LVAD
Start date: January 2014
Phase: N/A
Study type: Observational

End stage heart failure is characterized by a critical inability of the heart to meet the organism's blood demand even under resting conditions. Heart transplantation (HTx) is the established therapeutic approach in the treatment of end stage heart failure and still the gold standard treatment. Left ventricular assist devices (LVADs) are considered as a vital therapeutic option to temporarily or permanently assist the failing circulation. The hemodynamic vascular consequences of implanting LVADs have not been studied in detail. The aim of the study is to investigate the effect of LVAD implantation compared to heart transplant (HTx) on micro- and macrovascular function in patients with end stage heart failure.

NCT ID: NCT00490347 Completed - Cardiomyopathies Clinical Trials

VentrAssistTM LVAD as a Bridge to Cardiac Transplantation - Feasibility Trial

Start date: July 2005
Phase: Phase 2
Study type: Interventional

The purpose of this trial is to determine the safety and feasibility of the VentrAssist LVAD in providing circulatory support for patients who require an LVAD as a bridge to cardiac transplantation.

NCT ID: NCT00490321 Active, not recruiting - Cardiomyopathies Clinical Trials

VentrAssistTM LVAD for the Treatment of Advanced Heart Failure - Destination Therapy

Start date: June 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the safety and effectiveness of LVADs in providing long-term circulatory support for patients who have chronic stage D heart failure and are ineligible for a heart transplant. This is a multi-center, prospective, randomized, controlled clinical trial, which is comprised of two independent modules.

NCT ID: NCT00483197 Active, not recruiting - Cardiomyopathies Clinical Trials

VentrAssistTM LVAD as a Bridge to Cardiac Transplantation - Pivotal Trial

Start date: June 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the safety and effectiveness of VentrAssistTM LVAD in individuals who are awaiting heart transplants.