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Empyema clinical trials

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NCT ID: NCT00798278 Completed - Pneumonia Clinical Trials

Urokinase Versus Video-assisted Thoracoscopic to Treat Complicated Parapneumonic Empyema in Childhood

Start date: July 2008
Phase: Phase 3
Study type: Interventional

A great controversy exists about which is the best method to perform the evacuation of the collection. The purpose of this study is to evaluate which is the best initial treatment to drain complicated parapneumonic empyema (stages II and III) in children: the present study raises a hypothesis of equivalence between both arms of treatment (chest drainage plus intrapleural urokinase or videothoracoscopic debridement).

NCT ID: NCT00502632 Recruiting - Pleural Empyema Clinical Trials

Dornase Alfa and Urokinase for Kids With Pleural Empyema

DUKE
Start date: October 2007
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to determine whether intrapleural treatment with Dornase alfa plus Urokinase improves clinical outcome compared to Urokinase alone in children with complicated parapneumonic effusions

NCT ID: NCT00468104 Completed - Clinical trials for Pleural Effusion Associated With Pulmonary Infection

Efficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/Empyemas

CPE
Start date: April 2004
Phase: N/A
Study type: Interventional

The purpose of this study is to document the efficacy and safety of intrapleural instillation of Activase vs Placebo in the management of complicated pleural effusions and empyemas

NCT ID: NCT00323531 Completed - Empyema Clinical Trials

Thoracoscopy Versus Fibrinolysis in Children With Empyema

Start date: March 2006
Phase: Phase 2/Phase 3
Study type: Interventional

The null hypothesis is that patients receiving either thoracoscopy or fibrinolysis for empyema recover in the same amount of time. Therefore, we will test this by randomizing the next 40 patients who consent to the study to one treatment or the other.

NCT ID: NCT00313066 Recruiting - Tuberculosis Clinical Trials

Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion

Start date: November 2005
Phase: Phase 4
Study type: Observational

Connective tissue growth factor (CTGF) is known to be a fibrogenic cytokine, it could be expressed in various fibrosis diseases. But, recent research showed that CTGF also be considered to be a tumor suppressive gene. The expression of CTGF protein is higher in normal Type I and II alveolar epithelial cells than metastatic tumor cells. CTGF appears to be a suppressor of lung tumor invasion and in metastasis and the decreased CTGF expression in tumor tissues was associated with advanced tumor stage, lymph node metastasis, early postoperative relapse and shorter patient survival. CTGF can be expressed in many human organs such as heart, brain, placenta, liver, muscle, kidney, peritoneal mesothelial cells and lung but did not known in the pleura. The CTGF protein is present in the peritoneal cavity and is increased during peritonitis. Considering pleural cavity comes from the same origin of mesenchyma with peritoneum, pericardium and fallopian tube, we aim to evaluate whether the CTGF expression increase in the pleurisy patients including the parapneumonic effusion and the TB pleurisy. The diagnosis of TB pleurisy depends on the effusion TB culture and pleural biopsy. Unfortunately the sensitivity of TB culture was only 20-30%. So most patients must receive invasive pleural biopsy. Adenosine deaminase(ADA) was developed as a screening test but should not be considered an alternative test to culture and biopsy. The sensitivity of ADA might vary from 32%-100% and the cutoff value also vary from 26 to 70 IU/L. We should develop a method to alternate the culture and biopsy . Therefore, our technologist Jao-Jia chu will develop the CTGF ELISA kit for this specific aim. If CGTF might increase expression in pleuritis but decrease in pleural metastasis, it might be a potential method help to differentiate lymphocytic pleural effusion between TB pleurisy and malignancy.

NCT ID: NCT00234208 Terminated - Pleural Empyema Clinical Trials

Early Medical Thoracoscopy Versus Simple Chest Tube Drainage in Complicated Parapneumonic Effusion and Pleural Empyema

Start date: October 2005
Phase: Phase 3
Study type: Interventional

Multicenter, randomized controlled study to compare early mini-invasive thoracoscopy to simple chest tube drainage in complicated parapneumonic effusions or pleural empyema. 100 patients will be recruited. Follow-up will be 3 months. It will be looked at the rate medical cure, the need for secondary interventions, death and duration of hospital stay. In a nested trial in 20 patients the intrapleural pharmacokinetics of linezolid (approved antibiotic agent) will be measured.

NCT ID: NCT00144950 Completed - Empyema Clinical Trials

Urokinase Versus Primary Video-Assisted Thorascopic Surgery for Empyema

Start date: n/a
Phase: Phase 1
Study type: Interventional

This study will compare VATS versus chest drain insertion and urokinase in the treatment of childhood empema by a randomised prospective study.

NCT ID: NCT00103766 Recruiting - Pleural Effusion Clinical Trials

Alteplase for Treatment of Empyema and Complicated Parapneumonic Effusion

Start date: October 2004
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the benefit to patients with empyema or complicated parapneumonic effusion (CPE) using a daily versus twice daily Alteplase regimen of two different dose strategies compared with saline placebo.