Dornase Alfa and Urokinase for Kids With Pleural Empyema — DUKE

Pleural Empyema Clinical Trial

Official title:
Multicentre Randomized Double-Blinded Trial of Intrapleural Dornase Alfa and Urokinase vs Urokinase Alone for Complicated Parapneumonic Effusions in Children

Status Recruiting

Clinical Trial Summary

The purpose of this study is to determine whether intrapleural treatment with Dornase alfa plus Urokinase improves clinical outcome compared to Urokinase alone in children with complicated parapneumonic effusions

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00502632
Study type	Interventional
Source	Azienda Ospedaliera di Padova
Contact	PierGiorgio Gamba, MD
Phone	+39 049 821 3683
Email	piergiorgio.gamba@unipd.it
Status	Recruiting
Phase	Phase 2/Phase 3
Start date	October 2007
Completion date	October 2009

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See also
Status	Clinical Trial	Phase
Recruiting	`NCT04095676` - VATS Surgery Compared to Drainage in the Treatment of Pleural Empyema	N/A
Completed	`NCT01011881` - Procalcitonin in Pleural Pleuritis	N/A
Terminated	`NCT00234208` - Early Medical Thoracoscopy Versus Simple Chest Tube Drainage in Complicated Parapneumonic Effusion and Pleural Empyema	Phase 3
Active, not recruiting	`NCT05077111` - A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia	Phase 4
Completed	`NCT01717742` - Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial)	Phase 3