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Alteration of Symbiosis Intestinal Microbiota on Patients With Anorexia Nervosa — INT-METAVOSA  

Anorexia Nervosa Clinical Trial

Official title:
Study of Translational Process of Relationship Between Intestinal Microbiota of Dysbiosis and the Psychic Symptoms of Anorexia Nervosa (Eating Disorders and Anxio-depression Disorders)

Clinical Trial Summary

The purpose of this study will be to study the association between the level of psychic symptomatic of anorexia nervosa (AN) (intensity of food restriction, symptoms of anxiety and depression) and alteration of host environment symbiosis and the mechanism (dysbiosis of intestinal microbiota, increase of intestinal permeability, immunity alteration and low-grade inflammation).

Clinical Trial Description

This is a monocentric study aims to characterise the intestinal microbiota of anorexia nervosa patients with malnutrition, in comparison with the control subject, by DNA sequencing and metagenomic method. The interaction of intetinal microbiota with the host will be studied through the mecanistic studies and various parameters of alteration of symbiosis (intestinal permeability, inflammation) and their association with psychic symptoms of anorexia nervosa. The objective of this approche is to have not only a descrition of genomic of material of sampling, but also an overview of its potential functioning. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05632497
Study type Observational
Source Assistance Publique - Hôpitaux de Paris
Contact Mouna HANACHI GUIDOUM, MD
Phone + 33 6 70 39 42 37
Email mouna.hanachi@aphp.fr
Status Recruiting
Phase
Start date May 23, 2024
Completion date July 2025
View Details
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