Stroke, Acute Clinical Trial
Official title:
Assessing Accuracy of Clinical Diagnosis and Lesion Location in Acute Neurological Deficits - How Good Are Neurologists?
The emergency setting for acute neurological conditions, such as stroke, is peculiar due to time pressure and limited resources for further diagnostics. Clinical skills are essential for swift and accurate bedside diagnosis and thus are the basis for early and correct treatment. This is especially evident in the context of computed tomography being the standard neuroimaging method world-wide with its limitations for detecting smaller infarcts, strokes in the posterior fossa and reduced sensitivity for stroke mimics, such as epileptic seizures or migraine aura. To date, the accuracy of clinical bedside diagnosis of stroke by neurologists verified by magnetic resonance imaging (MRI) in the emergency setting has not been studied in detail. In order to improve clinical diagnosing and future treatment it is essential to quantify the accuracy of clinical diagnosis of stroke in the emergency setting ("how good are neurologists?") and to assesses whether there are any differences between experienced staff neurologists and junior physicians.
Background:
The emergency setting for acute neurological conditions, such as stroke, is peculiar due to
time pressure and limited resources for further diagnostics. Clinical skills are essential
for swift and accurate bedside diagnosis and thus are the basis for early and correct
treatment. This is especially evident in the context of computed tomography being the
standard neuroimaging method world-wide with its limitations for detecting smaller infarcts,
strokes in the posterior fossa and reduced sensitivity for stroke mimics, such as epileptic
seizures or migraine aura. To date, the accuracy of clinical bedside diagnosis of stroke by
neurologists verified by magnetic resonance imaging (MRI) in the emergency setting has not
been studied in detail. Management of acute stroke patients is a main interest of the
neurovascular research group at Inselspital Bern. For example, the investigators analysed the
prediction of large vessel occlusion in acute stroke patients by clinical examination and
found a significant association of stroke severity measured with the NIHSS score and location
of vessel occlusion. Analysis of outcome in stroke patients with mild and rapidly improving
symptoms demonstrated that three of four of these patients had a favourable outcome, but
those with a central vessel occlusion were likely to deteriorate with poor outcome. These
studies showed that there is a correlation of clinical symptoms with the mechanism of stroke,
which is important for the outcome after treatment. Importantly, however, the quality of
clinical assessment itself is likely highly variable, for example depending on the experience
of the treating physician. Factors influencing this clinical assessment, which needs to be
done under high temporal and emotional pressure in the emergency setting have not been
investigated so far but might be crucial for rapid and successful treatment ("time is
brain").In order to improve clinical diagnosing and future treatment it is essential to
quantify the accuracy of clinical diagnosis of stroke in the emergency setting ("how good are
neurologists?") and to assesses whether there are any differences between experienced staff
neurologists and junior physicians.
Rationale:
By assessing whether prediction of aetiology of acute neurological deficits is
experience-based the investigators aim to understand what symptoms/signs impede the
in-experienced from swiftly making the correct diagnosis in the emergency setting. This
should help to improve resident training and with this treatment of patients with acute
neurological deficits.
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